State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University , Guangzhou , China.
Curr Eye Res. 2019 Oct;44(10):1104-1111. doi: 10.1080/02713683.2019.1627461. Epub 2019 Jun 13.
: To investigate vasculature-function and structure-function relationship in healthy myopic eyes using optical coherence tomography angiography (OCT-A), optical coherence tomography (OCT) and microperimetry (MAIA). : A total of 370 eyes from 190 participants were enrolled in this study. Subjects divided into three groups based on refractive status: low myopia (LM) (-3.00D ≤ spherical equivalent, SE ≤ -0.50D), moderate myopia (MM) (-6.00D ≤ SE < -3.00D) and high myopia (HM) (SE < -6.00D). The vessel density (VD), retinal thickness (RT) and light sensitivity (LS) were evaluated using OCT-A, OCT and MAIA. The global and regional vasculature-function and structure-function relationship were evaluated by the semi-partial correlation analysis according to ETDRS grid. The uni- and multivariate linear regression models were performed using LS as the dependent variable and covariates, included age, gender, intraocular pressure (IOP), axial length (AL), SE, ganglion cell complex thickness (GCCT), superficial (SVD) and deep vessel density (DVD) and RT as independent variables. : The LS negatively correlated with AL and positively correlated with SE, DVD, RT and GCCT ( < .05). The DVD was associated with the corresponding LS only in temporal and nasal sectors in HM (sr: 0.182-0.195, < .05) but SVD not at all. The RT was associated with the corresponding LS in inferior and nasal sectors in MM (sr: 0.221-0.281, < .005) and all sectors in HM (sr: 0.187-0.229, < .05). Lower DVD and RT were independently associated with the declined LS in myopic eyes ( < .05). : Reduced DVD and RT were independently associated with the declined LS in healthy myopic eyes, especially in HM.
应用光学相干断层扫描血管造影（OCT-A）、光学相干断层扫描（OCT）和微视野计（MAIA）研究健康近视眼中的血管-功能和结构-功能关系。
本研究共纳入 190 名参与者的 370 只眼。根据屈光状态将受试者分为三组：低度近视（LM）（等效球镜-3.00D≤SE≤-0.50D）、中度近视（MM）（-6.00D≤SE＜-3.00D）和高度近视（HM）（SE＜-6.00D）。采用 OCT-A、OCT 和 MAIA 评估血管密度（VD）、视网膜厚度（RT）和光敏感度（LS）。根据 ETDRS 网格，采用偏相关分析评估全视网膜和局部血管-功能和结构-功能关系。以 LS 为因变量，年龄、性别、眼压（IOP）、眼轴（AL）、SE、神经节细胞复合体厚度（GCCT）、浅层（SVD）和深层血管密度（DVD）和 RT 为自变量，进行单变量和多变量线性回归模型分析。
LS 与 AL 呈负相关，与 SE、DVD、RT 和 GCCT 呈正相关（<0.05）。在 HM 中，DVD 仅与颞侧和鼻侧相应的 LS 相关（sr：0.182-0.195，<0.05），而 SVD 则无相关性。在 MM 中，RT 与鼻侧和下侧相应的 LS 相关（sr：0.221-0.281，<0.005），在 HM 中与所有象限的 LS 相关（sr：0.187-0.229，<0.05）。较低的 DVD 和 RT 与近视眼中 LS 的下降独立相关（<0.05）。
在健康近视眼中，较低的 DVD 和 RT 与 LS 的下降独立相关，尤其是在 HM 中。
