Miraftabi Arezoo, Moghadam Fard Atusa, Yavari Azadeh, Nilforushan Naveed, Chaibakhsh Samira, Abolfathzadeh Navid
Eye Research Center, The Five Senses Institute, Rassoul Akram Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Rajaee Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
Med J Islam Repub Iran. 2025 Feb 5;39:21. doi: 10.47176/mjiri.39.21. eCollection 2025.
There have been different reports of the retinal nerve fiber layer (RNFL) thickness in myopic and hyperopic patients in optical coherence tomography (OCT)-based studies. This study was conducted to evaluate the correlation between vascular density of the optic nerve head and refractive errors in healthy subjects using OCT-angiography (OCTA).
In a prospective interventional case series, 47 healthy subjects were enrolled consequently. The target spherical equivalent was -1.00 to +1.00, -1.00 to -6.00, and +1.00 to +4.00 in the emmetropia group (A), myopia group (B), and hyperopia group (C), respectively. The astigmatism was less than 3.00 diopters in all patients. The thickness of the retinal nerve fiber layer (RNFL), the vascular density of the optic nerve head (ONH), and the peripapillary area were measured. Statistical independent samples t-tests were used to evaluate between-group differences and the hyperopia group (group C) was considered as the reference group.
Eighty-eight eyes from 47 patients were included. Twenty-five eyes (28.4%) were emmetrope, 27 eyes (30.7%) were myopic, and 36 eyes (40.9%) were hyperopic. The mean rim area was significantly lower in myopic eyes than in hyperopic eyes (1.64 vs. 1.80, =0.039). Although the lowest mean of RNFL thickness was observed in myopic eyes, the difference between groups was not statistically significant. The nasal radial peripapillary capillaries (RPC) were significantly lower in myopic eyes versus hyperopic (49.04 vs.52.72, =0.006). There was not any significant difference between the mean of RPC capillary inside the disc.
The vascular density in the RPC area was significantly lower in myopic eyes than in hyperopic and emmetropic eyes.
在基于光学相干断层扫描（OCT）的研究中，关于近视和远视患者视网膜神经纤维层（RNFL）厚度有不同的报道。本研究旨在使用光学相干断层扫描血管造影（OCTA）评估健康受试者视神经乳头血管密度与屈光不正之间的相关性。
在一项前瞻性干预性病例系列研究中，最终纳入了47名健康受试者。正视组（A组）、近视组（B组）和远视组（C组）的目标球镜等效度数分别为-1.00至+1.00、-1.00至-6.00和+1.00至+4.00。所有患者的散光均小于3.00屈光度。测量视网膜神经纤维层（RNFL）厚度、视神经乳头（ONH）血管密度和视乳头周围区域。采用统计学独立样本t检验评估组间差异，远视组（C组）被视为参照组。
纳入了47例患者的88只眼。25只眼（28.4%）为正视眼，27只眼（30.7%）为近视眼，36只眼（40.9%）为远视眼。近视眼的平均视盘边缘面积显著低于远视眼（1.64对1.80，P=0.039）。虽然近视眼的RNFL厚度均值最低，但组间差异无统计学意义。近视眼的鼻侧视乳头周围毛细血管（RPC）明显低于远视眼（49.04对52.72，P=0.006）。视盘内RPC毛细血管的均值之间无显著差异。
近视眼视乳头周围毛细血管区域的血管密度显著低于远视眼和正视眼。
