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没食子酸的神经生物学效应:当前观点

Neurobiological effects of gallic acid: current perspectives.

作者信息

Bhuia Md Shimul, Rahaman Md Mizanur, Islam Tawhida, Bappi Mehedi Hasan, Sikder Md Iqbal, Hossain Kazi Nadim, Akter Fatama, Al Shamsh Prottay Abdullah, Rokonuzzman Md, Gürer Eda Sönmez, Calina Daniela, Islam Muhammad Torequl, Sharifi-Rad Javad

机构信息

Department of Pharmacy, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, 8100, Bangladesh.

Department of Pharmacy, Southern University Bangladesh, Chattogram, 4210, Bangladesh.

出版信息

Chin Med. 2023 Mar 15;18(1):27. doi: 10.1186/s13020-023-00735-7.

Abstract

Gallic acid (GA) is a phenolic molecule found naturally in a wide range of fruits as well as in medicinal plants. It has many health benefits due to its antioxidant properties. This study focused on finding out the neurobiological effects and mechanisms of GA using published data from reputed databases. For this, data were collected from various sources, such as PubMed/Medline, Science Direct, Scopus, Google Scholar, SpringerLink, and Web of Science. The findings suggest that GA can be used to manage several neurological diseases and disorders, such as Alzheimer's disease, Parkinson's disease, strokes, sedation, depression, psychosis, neuropathic pain, anxiety, and memory loss, as well as neuroinflammation. According to database reports and this current literature-based study, GA may be considered one of the potential lead compounds to treat neurological diseases and disorders. More preclinical and clinical studies are required to establish GA as a neuroprotective drug.

摘要

没食子酸(GA)是一种酚类分子,天然存在于多种水果以及药用植物中。由于其抗氧化特性,它对健康有诸多益处。本研究利用知名数据库中已发表的数据,着重探究没食子酸的神经生物学效应及作用机制。为此,从多个来源收集了数据,如PubMed/Medline、Science Direct、Scopus、谷歌学术、SpringerLink和科学网。研究结果表明,没食子酸可用于治疗多种神经疾病和紊乱,如阿尔茨海默病、帕金森病、中风、镇静、抑郁、精神病、神经性疼痛、焦虑和记忆力减退,以及神经炎症。根据数据库报告和这项基于当前文献的研究,没食子酸可能被视为治疗神经疾病和紊乱的潜在先导化合物之一。需要更多的临床前和临床研究来确立没食子酸作为一种神经保护药物的地位。

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