Hsieh K H
Ann Allergy. 1979 Mar;42(3):187-91.
Forty-seven asthmatic children and eight non-allergic adults were studied by the co-culture technique of Wadman et al to test the postulated deficiency of IgE suppressor T-cell function in allergic patients. The results showed that (1) lymphocytes from asthmatic children synthesize more IgE than those from normal adults, (2) there was no correlation between serum IgE and in vitro IgE biosynthesis, (3) co-culture of lymphocytes from normal adults and patients often resulted in deviation, both enhancing and inhibiting, from expected values; therefore, no consistent suppressor T-cell defect could be demonstrated in patients; and (4) after hyposensitization, while there was a tendency for the serum IgE to decline, the capability of IgE biosynthesis tended to increase.
采用瓦德曼等人的共培养技术对47名哮喘儿童和8名非过敏成人进行了研究，以检验过敏患者中假定的IgE抑制性T细胞功能缺陷。结果显示：（1）哮喘儿童的淋巴细胞比正常成人的淋巴细胞合成更多的IgE；（2）血清IgE与体外IgE生物合成之间无相关性；（3）正常成人和患者的淋巴细胞共培养常常导致与预期值的偏差，既有增强也有抑制；因此，在患者中未能证实存在一致的抑制性T细胞缺陷；（4）脱敏后，虽然血清IgE有下降趋势，但IgE生物合成能力有增加趋势。
