Hsieh K H
Ann Allergy. 1981 Sep;47(3):186-8.
Monocyte regulation of IgE biosynthesis was studied in 20 asthmatic children and 20 healthy normals. The monocytes (MN's) were separated from mononuclear cells (MNC's) by plastic petri dish adherence and part of them were activated by lippopolysaccharide (LPS, 2 micrograms/ml for 1 hour). The results showed that (1) MNCs of patients produced much more IgE than did the MNC's of normals, (2) monocyte-depletion resulted in decreased IgE production of patients' MNC's but not normals' MNC's (3) monocytes of patients could enhance the IgE-synthesizing capability of T cell activity in IgE biosynthesis in both allergic patients and normals. It is, therefore, concluded that there exist in allergic patients suppressor adherent cells which suppress the regulatory T cell function and may play a certain role in the immunopathogenesis of augmented IgE production in atopic individuals.
对20名哮喘儿童和20名健康正常人的单核细胞对IgE生物合成的调节作用进行了研究。通过塑料培养皿贴壁法从单个核细胞（MNC）中分离出单核细胞（MN），其中一部分单核细胞用脂多糖（LPS，2微克/毫升，作用1小时）激活。结果显示：（1）患者的MNC产生的IgE比正常人的MNC多得多；（2）去除单核细胞导致患者MNC的IgE产生减少，但正常人的MNC未减少；（3）患者的单核细胞可增强变应性患者和正常人的T细胞活性在IgE生物合成中合成IgE的能力。因此得出结论，变应性患者体内存在抑制性贴壁细胞，其抑制调节性T细胞功能，可能在特应性个体IgE产生增加的免疫发病机制中起一定作用。
