Zhou Christine Y, Ricker Melissa, Pathak Vikas
Department of Medicine, Campbell University School of Osteopathic Medicine, Lillington, North Carolina, USA.
Department of Pulmonary and Critical Care, Atrium Health, Charlotte, North Carolina, USA.
Clin Med Res. 2019 Jun;17(1-2):34-36. doi: 10.3121/cmr.2019.1447.
Cocaine can cause a myriad of changes in the lung, which can range from bronchoconstriction to destruction of the alveolar-capillary membrane and acute lung injury. Cocaine-induced bronchospasm is a diagnosis of exclusion that should be considered when the clinical presentation of acute hypoxic and hypercapneic respiratory failure cannot be explained by chronic obstructive pulmonary disease or asthma exacerbation, anaphylaxis to food or medications, exercise, or infection. Here, we present two patients with acute hypoxic and hypercapneic respiratory failure that was ultimately attributed to cocaine use shortly prior to symptom onset.
可卡因可导致肺部出现无数变化，范围从支气管收缩到肺泡-毛细血管膜破坏及急性肺损伤。可卡因诱发的支气管痉挛是一种排除性诊断，当急性低氧和高碳酸血症性呼吸衰竭的临床表现不能用慢性阻塞性肺疾病或哮喘加重、食物或药物过敏、运动或感染来解释时，就应考虑这一诊断。在此，我们报告两名急性低氧和高碳酸血症性呼吸衰竭患者，其最终病因被认定为症状发作前不久使用了可卡因。
