Department of Internal Medicine (Relocated to New York University as Clinical Instructor and Hospitalist), Maimonides Medical Center, 4810 10th Avenue, Brooklyn, NY, 11219, USA.
Department of Neurology, Maimonides Medical Center, 4810 10th Avenue, Brooklyn, NY, 11219, USA.
Cerebellum. 2019 Dec;18(6):1126-1129. doi: 10.1007/s12311-019-01045-1.
Paraneoplastic cerebellar degeneration (PCD) is a rare disorder that is associated with lung or gynecological malignancies and Hodgkin lymphoma. Neurologic symptoms are commonly the initial presenting sign leading to the diagnosis of an underlying malignancy. We are presenting an Asian male with progressive lower extremity weakness with EBV-positive nasopharyngeal carcinoma (NPC) and anti-Yo antibodies. Peculiarly, transient diffuse leptomeningeal enhancement is seen on MR imaging. This is the first report of PCD associated with NPC and thus illustrates that PCD embodies a boarder set of disease than previously described.
副肿瘤性小脑变性（PCD）是一种罕见的疾病，与肺癌或妇科恶性肿瘤和霍奇金淋巴瘤有关。神经系统症状通常是导致潜在恶性肿瘤诊断的首发表现。我们报告了一例亚洲男性，患有进行性下肢无力，伴 EBV 阳性鼻咽癌（NPC）和抗 Yo 抗体。磁共振成像（MRI）显示脑膜有短暂弥漫性增强，这是首例 NPC 相关 PCD 的报道，因此表明 PCD 所包含的疾病谱比以前描述的更广泛。
