Kidney Research Laboratory, Division of Nephrology, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu 610041, China.
Curr Med Chem. 2020;27(34):5829-5854. doi: 10.2174/0929867325666190603110907.
Toll-like Receptors (TLRs) are members of pattern recognition receptors and serve a pivotal role in host immunity. TLRs response to pathogen-associated molecular patterns encoded by pathogens or damage-associated molecular patterns released by dying cells, initiating an inflammatory cascade, where both beneficial and detrimental effects can be exerted. Accumulated evidence has revealed that TLRs are closely associated with various kidney diseases but their roles are still not well understood. This review updated evidence on the roles of TLRs in the pathogenesis of kidney diseases including urinary tract infection, glomerulonephritis, acute kidney injury, transplant allograft dysfunction and chronic kidney diseases.
Toll 样受体 (TLRs) 是模式识别受体的成员，在宿主免疫中起着关键作用。TLRs 对病原体编码的病原体相关分子模式或死亡细胞释放的损伤相关分子模式作出反应，引发炎症级联反应，其中可能产生有益和有害的影响。越来越多的证据表明，TLRs 与各种肾脏疾病密切相关，但它们的作用仍不清楚。本综述更新了 TLRs 在尿路感染、肾小球肾炎、急性肾损伤、移植移植物功能障碍和慢性肾脏病等肾脏疾病发病机制中的作用证据。
