成年家禽的急性全身性过敏反应——血管活性脂质和肽的可能作用

Acute systemic anaphylaxis in adult domestic fowl--possible role of vasoactive lipids and peptides.

作者信息

Chand N, Eyre P

出版信息

Arch Int Pharmacodyn Ther. 1978 Nov;236(1):164-76.

Abstract

Bovine albumin (BA: 2 mg/kg-1, i.v.) produced a fall in systemic arterial blood pressure accompanied by central venous hypertension and bradycardia in pentobarbital-anaesthetized, spontaneously breathing, bovine albumin-sensitized adult domestic fowl. Trasylol (a potent inhibitor of kallikreins) suppressed acute systemic anaphylaxis. Polyphloretin phosphate (an effective antagonist of PGF2alpha) also inhibited the cardiovascular responses to antigen and PGF2alpha. Sodium meclofenamate and phenylbutazone showed varying degree of blockade of cardiovascular responses to exogenously administered chemical mediators (bradykinik, PGF2alpha, SRS-A and to a lesser extent of histamine, 5-HT and acetylcholine) and antigen. Indomethacin (virtually devoid of receptor blocking activities toward exogenously injected chemical mediators) inhibited anaphylaxis. The results of this investigation strongly suggested an important role of vasoactive lipids and polypeptides in avian anaphylaxis.

摘要

在戊巴比妥麻醉、自主呼吸、对牛白蛋白致敏的成年家禽中，静脉注射牛白蛋白（BA：2mg/kg-1）导致全身动脉血压下降，伴有中心静脉高压和心动过缓。抑肽酶（一种强力激肽释放酶抑制剂）可抑制急性全身过敏反应。聚磷酸根皮苷（一种有效的前列腺素F2α拮抗剂）也能抑制对抗原和前列腺素F2α的心血管反应。甲氯芬那酸钠和保泰松对外源性化学介质（缓激肽、前列腺素F2α、慢反应物质-A，以及程度较轻的组胺、5-羟色胺和乙酰胆碱）和抗原引起的心血管反应有不同程度的阻断作用。吲哚美辛（实际上对外源性注射的化学介质几乎没有受体阻断活性）可抑制过敏反应。这项研究结果强烈表明血管活性脂质和多肽在禽类过敏反应中起重要作用。