a Department of Medical Physiology, School of Medicine, University of Granada , Granada , Spain.
b PROFITH "PROmoting FITness and Health through physical activity" Research Group, Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada , Granada , Spain.
J Sports Sci. 2019 Oct;37(19):2175-2183. doi: 10.1080/02640414.2019.1626048. Epub 2019 Jun 4.
This study aimed to investigate the effects of different training modalities on the soluble Klotho (S-Klotho) plasma levels in sedentary middle-aged adults. A total of 74 middle-aged adults (53.4 ± 5.0 years old; 52.7% women) were enrolled in the FIT-AGEING study. We conducted a 12-week randomised controlled trial. The participants were randomly assigned to 4 different groups: (i) a control group (no exercise), (ii) a physical activity recommendation from the World Health Organization group (PAR), (iii) a high intensity interval training group (HIIT), and (iv) a high intensity interval training group adding whole-body electromyostimulation training group (HIIT-EMS). S-Klotho plasma levels, anthropometric measurements, and body composition variables were measured before and after the intervention programme. All exercise training modalities induced an increase in the S-Klotho plasma levels (all P ≤ 0.019) without statistical differences between them (all P ≥ 0.696). We found a positive association between changes in lean mass index and changes in the S-Klotho plasma levels, whereas a negative association was reported between changes in fat mass outcomes and changes in the S-Klotho plasma levels after our intervention study. In conclusion, our results suggest that the link between exercise training and the increase in S-Klotho plasma levels could be mediated by a decrease of fat mass and an increase of lean mass.
本研究旨在探讨不同训练方式对久坐中年成年人可溶性 Klotho（S-Klotho）血浆水平的影响。共有 74 名中年成年人（53.4±5.0 岁；52.7%为女性）参与了 FIT-AGEING 研究。我们进行了一项 12 周的随机对照试验。参与者被随机分配到 4 个不同的组：（i）对照组（不运动），（ii）世界卫生组织推荐的身体活动组（PAR），（iii）高强度间歇训练组（HIIT），和（iv）高强度间歇训练组加全身肌电刺激训练组（HIIT-EMS）。在干预计划前后测量了 S-Klotho 血浆水平、人体测量学测量和身体成分变量。所有运动训练方式均导致 S-Klotho 血浆水平升高（所有 P≤0.019），但它们之间无统计学差异（所有 P≥0.696）。我们发现，瘦体重指数的变化与 S-Klotho 血浆水平的变化之间存在正相关，而脂肪量的变化与 S-Klotho 血浆水平的变化之间存在负相关。我们的干预研究。总之，我们的结果表明，运动训练与 S-Klotho 血浆水平升高之间的联系可能是通过减少脂肪量和增加瘦体重来介导的。
