Robbins T W, Everitt B J
Department of Experimental Psychology, University of Cambridge, U.K.
Neuropharmacology. 1987 Jul;26(7B):893-901. doi: 10.1016/0028-3908(87)90067-0.
The effects of lesions of the major catecholamine projections and terminal fields induced by 6-hydroxydopamine (6-OHDA), and of lesions of the cholinergic cells in the ventral pallidum/substantia innominata induced by ibotenic acid were compared within a single behavioural paradigm, the acquisition and performance of an appetitive conditional discrimination. Lesions of the coeruleo-cortical noradrenergic pathway induced by 6-OHDA produced over 90% depletion of noradrenaline in the neocortex and hippocampus and led to impairments in the acquisition, but not performance of the discrimination. Depletion of noradrenaline (NA) in the hypothalamus, produced by lesions of the rostral medullary noradrenergic cells, had no effect. Lesions of the caudate-putamen induced by 6-OHDA produced about an 80% depletion of dopamine and led to profound deficits in both the acquisition and performance of the discrimination, also retarding the latency to collect earned food pellets. Lesions of the nucleus accumbens, producing 80% depletion of dopamine from this structure had no significant effect on the acquisition or performance of the task. Lesions of the cholinergic cells in the ventral pallidum/substantia innominata induced by ibotenic acid, depending upon their size, had significant effects on the acquisition and performance of the discrimination, without affecting the latency to collect the pellets. Various problems of interpretation are discussed and the utility of a comparison of the different patterns of the effects of these lesions of catecholaminergic and cholinergic projections is made clear.
在单一行为范式（即获得性和执行性的条件性辨别）中，比较了6-羟基多巴胺（6-OHDA）诱导的主要儿茶酚胺投射和终末场损伤的影响，以及鹅膏蕈氨酸诱导的腹侧苍白球/无名质胆碱能细胞损伤的影响。6-OHDA诱导的蓝斑-皮质去甲肾上腺素能通路损伤导致新皮质和海马中去甲肾上腺素耗竭超过90%，并导致在获得性方面出现损伤，但不影响辨别的执行。延髓头端去甲肾上腺素能细胞损伤导致下丘脑去甲肾上腺素（NA）耗竭，对此并无影响。6-OHDA诱导的尾状核-壳核损伤导致多巴胺耗竭约80%，并导致在辨别任务的获得和执行方面出现严重缺陷，还延长了获取奖励食物颗粒的潜伏期。伏隔核损伤导致该结构中多巴胺耗竭80%，对任务的获得或执行没有显著影响。鹅膏蕈氨酸诱导的腹侧苍白球/无名质胆碱能细胞损伤，根据其大小不同，对辨别任务的获得和执行有显著影响，但不影响获取颗粒的潜伏期。文中讨论了各种解释问题，并明确了比较这些儿茶酚胺能和胆碱能投射损伤不同效应模式的实用性。
