Habiyaremye I, Verbist L, Vandepitte J
Laboratoire de Bactériologie, Clinique Universitaire St Raphaël, Leuven, Belgique.
Pathol Biol (Paris). 1987 Jun;35(5 Pt 2):800-4.
The susceptibility has been determined of 169 Shigella spp., 93 Salmonella spp., 68 Yersinia enterocolitica, 34 Vibrio cholerae 0:1, and 34 Campylobacter jejuni, isolated in Central Africa and in Belgium, to ten fluoroquinolones: ciprofloxacin, ofloxacin, norfloxacin, pefloxacin, enoxacin, amifloxacin, CI-934, A-56619, A-56620 and RO 23-6240. All quinolones were active against the strains tested, showing an MIC90 between 0.004 mg/l and 2 mg/l for strains susceptible to nalidixic acid and an MIC90 between 0.12 and 4 mg/l for resistant strains. Ciprofloxacin was the most active compound against Shigella spp., Salmonella spp. and Y. enterocolitica. A-56620 was the most active against C. jejuni; and both compounds were equal in activity against V. cholerae. The MBCs of all ten compounds were either similar to the MIC or one concentration higher. Killing curves show that the quinolones are bactericidal for the strains tested within 2 to 8 h of contact with concentrations corresponding to 2 or 8 times the MIC.
已测定从中非和比利时分离出的169株志贺氏菌属、93株沙门氏菌属、68株小肠结肠炎耶尔森氏菌、34株霍乱弧菌0:1和34株空肠弯曲菌对十种氟喹诺酮类药物的敏感性：环丙沙星、氧氟沙星、诺氟沙星、培氟沙星、依诺沙星、阿米氟沙星、CI-934、A-56619、A-56620和RO 23-6240。所有喹诺酮类药物对测试菌株均有活性，对萘啶酸敏感的菌株MIC90在0.004 mg/l至2 mg/l之间，耐药菌株的MIC90在0.12至4 mg/l之间。环丙沙星是对志贺氏菌属、沙门氏菌属和小肠结肠炎耶尔森氏菌最具活性的化合物。A-56620对空肠弯曲菌最具活性；这两种化合物对霍乱弧菌的活性相当。所有十种化合物的MBC与MIC相似或高一个浓度。杀菌曲线表明，喹诺酮类药物在与相当于MIC的2倍或8倍浓度接触2至8小时内对测试菌株具有杀菌作用。
