Jin Kunlin
Department of Pharmacology & Neuroscience, University of North Texas Health Science Center, TX 76107, USA.
Aging Dis. 2019 Jun 1;10(3):676-683. doi: 10.14336/AD.2019.0315. eCollection 2019 Jun.
Aging is the progressive decline of physiological functions necessary for survival and reproduction. In gaining a better understanding of the inevitable aging process, the hope is to preserve, promote, or delay healthy aging through the treatment of common age-associated diseases. Although there are theories that try to explain the aging process, none of them seem to fully satisfy. Microcirculation describes blood flow through the capillaries in the circulatory system. The main functions of the microcirculation are the delivery of oxgen and nutrients and the removal of CO, metabolic debris, and toxins. The microcirculatory impairment or dysfunction over time will result in the accumulation of toxic products and CO and loss of nutrition supplementation and O in corresponding tissue systems or internal organs, which eventually affect normal tissue and organ functions, leading to aging. Therefore, I propose a microcirculatory theory of aging: aging is the process of continuous impairment of microcirculation in the body.
衰老是生存和繁殖所必需的生理功能的逐渐衰退。为了更好地理解不可避免的衰老过程，人们希望通过治疗常见的与年龄相关的疾病来维持、促进或延缓健康衰老。尽管有一些理论试图解释衰老过程，但似乎没有一个能完全令人满意。微循环描述的是血液在循环系统中通过毛细血管的流动。微循环的主要功能是输送氧气和营养物质以及清除二氧化碳、代谢废物和毒素。随着时间的推移，微循环障碍或功能失调会导致有毒产物和二氧化碳的积累，以及相应组织系统或内脏器官营养补充和氧气供应的丧失，最终影响正常组织和器官功能，导致衰老。因此，我提出了一种衰老的微循环理论：衰老是身体微循环持续受损的过程。
