Department of General Intensive Care Unit, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Department of General Intensive Care Unit, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Int J Infect Dis. 2019 Aug;85:114-116. doi: 10.1016/j.ijid.2019.05.033. Epub 2019 Jun 3.
We report the first case of pulmonary scedosporiosis detected by next-generation sequencing (NGS) from bronchoalveolar lavage fluid (BALF) in a 67-year-old male with bronchiectasis and hematopoietic failure. Scedosporium apiospermum is a ubiquitous organism present in the environment with intrinsic resistance to many antifungal agents. The patient developed respiratory failure, pulmonary consolidation, and septic shock shortly thereafter, and responded poorly to antifungal therapy. This case highlights the combined application of NGS and traditional fungal culture in the clinical diagnosis of pulmonary invasive fungal disease. NGS is proposed as an important adjunctive diagnostic approach for uncommon pathogens.
我们报告了首例通过支气管肺泡灌洗液（BALF）的下一代测序（NGS）检测到的肺生孢菌病，患者为 67 岁男性，患有支气管扩张症和造血功能衰竭。枝孢霉属是一种普遍存在于环境中的生物体，对许多抗真菌药物具有内在耐药性。此后不久，患者出现呼吸衰竭、肺部实变和感染性休克，对抗真菌治疗反应不佳。该病例强调了 NGS 和传统真菌培养在肺部侵袭性真菌感染临床诊断中的联合应用。NGS 被提议作为一种对罕见病原体的重要辅助诊断方法。
