Strause L, Saltman P, Glowacki J
Department of Biology, University of California, San Diego, La Jolla 92093.
Calcif Tissue Int. 1987 Sep;41(3):145-50. doi: 10.1007/BF02563794.
Subcutaneous implantation of devitalized demineralized bone powers (DBP) and mineral-containing bone particles (BP) into rats raised on either a control (C), low manganese and low copper (L), or manganese-deplete (D) diet, allowed the separate evaluation of bone formation and of bone resorption, respectively. DBP failed to induce chondrogenesis or osteogenesis in D rats. Cartilage formation was delayed in the L rats compared to C rats. There was significantly less resorption of BP by L and D rats than C rats. These results show multiple cellular effects of long-term manganese (Mn) and copper (Cu) deficiencies on bone metabolism including decreased osteogenesis and a decrease in osteoclast activity.
将失活的脱矿骨粉（DBP）和含矿物质的骨颗粒（BP）皮下植入分别采用对照（C）、低锰低铜（L）或缺锰（D）饮食饲养的大鼠体内，可分别对骨形成和骨吸收进行单独评估。DBP未能在D组大鼠中诱导软骨形成或骨生成。与C组大鼠相比，L组大鼠的软骨形成延迟。L组和D组大鼠对BP的吸收明显少于C组大鼠。这些结果表明，长期缺锰（Mn）和缺铜（Cu）对骨代谢具有多种细胞效应，包括成骨减少和破骨细胞活性降低。
