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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Muñoz M E, Esteller A, González J

Department of Physiology and Pharmacology, Faculty of Pharmacy, University of Salamanca, Spain.

Clin Sci (Lond). 1987 Oct;73(4):371-5. doi: 10.1042/cs0730371.

The effect of high bilirubin loads (60 mumol/kg twice daily for 2 days) on glucuronosyltransferase activity and biliary excretion of bilirubin was studied in Wistar rats. 2. The concentration of bilirubin in serum increased from 1.1 mumol/l in controls to 5.5 mumol/l after bilirubin pretreatment. 3. Bilirubin pretreatment led to a 25% increase in hepatic UDP-glucuronosyltransferase activity. Bilirubin Tm was increased by 22% and correlated positively with glucuronosyltransferase activity. 4. The output of conjugated bilirubin in bile was enhanced but no changes in the proportion of monoconjugates to disconjugates were observed. 5. Our data suggest that prolonged treatment with bilirubin can increase biliary bilirubin excretion by inducing glucuronosyltransferase activity.

在Wistar大鼠中研究了高胆红素负荷（每天两次，每次60 μmol/kg，持续2天）对葡萄糖醛酸转移酶活性和胆红素胆汁排泄的影响。2. 胆红素预处理后，血清胆红素浓度从对照组的1.1 μmol/L升至5.5 μmol/L。3. 胆红素预处理使肝脏UDP-葡萄糖醛酸转移酶活性增加25%。胆红素Tm增加22%，且与葡萄糖醛酸转移酶活性呈正相关。4. 胆汁中结合胆红素的排出量增加，但单结合物与双结合物的比例未观察到变化。5. 我们的数据表明，胆红素的长期治疗可通过诱导葡萄糖醛酸转移酶活性增加胆汁胆红素排泄。

Muñoz M E, Esteller A, González J

Department of Physiology and Pharmacology, Faculty of Pharmacy, University of Salamanca, Spain.

Clin Sci (Lond). 1987 Oct;73(4):371-5. doi: 10.1042/cs0730371.

The effect of high bilirubin loads (60 mumol/kg twice daily for 2 days) on glucuronosyltransferase activity and biliary excretion of bilirubin was studied in Wistar rats. 2. The concentration of bilirubin in serum increased from 1.1 mumol/l in controls to 5.5 mumol/l after bilirubin pretreatment. 3. Bilirubin pretreatment led to a 25% increase in hepatic UDP-glucuronosyltransferase activity. Bilirubin Tm was increased by 22% and correlated positively with glucuronosyltransferase activity. 4. The output of conjugated bilirubin in bile was enhanced but no changes in the proportion of monoconjugates to disconjugates were observed. 5. Our data suggest that prolonged treatment with bilirubin can increase biliary bilirubin excretion by inducing glucuronosyltransferase activity.

在Wistar大鼠中研究了高胆红素负荷（每天两次，每次60 μmol/kg，持续2天）对葡萄糖醛酸转移酶活性和胆红素胆汁排泄的影响。2. 胆红素预处理后，血清胆红素浓度从对照组的1.1 μmol/L升至5.5 μmol/L。3. 胆红素预处理使肝脏UDP-葡萄糖醛酸转移酶活性增加25%。胆红素Tm增加22%，且与葡萄糖醛酸转移酶活性呈正相关。4. 胆汁中结合胆红素的排出量增加，但单结合物与双结合物的比例未观察到变化。5. 我们的数据表明，胆红素的长期治疗可通过诱导葡萄糖醛酸转移酶活性增加胆汁胆红素排泄。