Department of Toxic Organic Pollutants, Faculty of Medicine, Slovak Medical University in Bratislava, Slovakia.
Mass Spectrometry Centre, Faculty of Chemistry, University of Vienna, Austria.
Chemosphere. 2019 Oct;233:387-395. doi: 10.1016/j.chemosphere.2019.05.284. Epub 2019 May 30.
Polybrominated diphenylethers (PBDEs) are persistent organic pollutants (POPs), they are considered endocrine disruptors and can bioaccumulate in nature, and in living tissue. Human exposure to and the presence of PBDEs in human samples is of concern due to their potential health risks. Young children are one of the most vulnerable populations to PBDE's potential health effects. Ninety-one serum samples of 6-year-old children, residing in a contaminated location, due to former production of polychlorinated biphenyls (PCBs), were analysed to examine children's exposure to PBDEs in Slovakia. Median serum concentrations found for individual PBDE congeners BDE-28, -47, -99, -100, -153, -154 and -183 were 0.015, 0.184, 0.079, 0.046, 0.176, 0.014, and 0.097 ng g lipid weight, respectively. Children's preschool maturity was measured using the Wechsler Preschool and Primary Scale of Intelligence (WPPSI-III) test. In multivariate analyses BDE-153 serum concentrations were significantly inversely associated with WPPSI-III composite score (p = 0.011, β = -23.6), while adjusting for PCB-153 and sex. Significant negative associations were observed for BDE-153 serum concentrations (p = 0.002, β = -29.8) and WPPSI-III composite score, after controlling for PCB-118 and sex. Negative associations were also observed for BDE-47, BDE-100 and BDE-153, with different individual WPPSI subtest scores, after adjustment with PCB-153 and/or PCB-118 and sex. Serum concentrations of PCB-153 and PCB-118 were not statistically significantly associated with WPPSI-III composite score and individual subtest scores. These findings demonstrate adverse effects of PBDE serum exposure on preschool maturity of children, and PBDEs potentially negative impact on child neuropsychological development.
多溴二苯醚（PBDEs）是持久性有机污染物（POPs），它们被认为是内分泌干扰物，可在自然界和生物组织中生物累积。由于其潜在的健康风险，人类接触和人体样本中 PBDE 的存在引起了关注。幼儿是最容易受到 PBDE 潜在健康影响的人群之一。对居住在一个因多氯联苯（PCBs）生产而受到污染的地方的 6 岁儿童的 91 份血清样本进行了分析，以检查斯洛伐克儿童接触 PBDE 的情况。发现个体 PBDE 同系物 BDE-28、BDE-47、BDE-99、BDE-100、BDE-153、BDE-154 和 BDE-183 的血清浓度中位数分别为 0.015、0.184、0.079、0.046、0.176、0.014 和 0.097ng/g 脂质重量。使用韦氏学前和小学智力量表（WPPSI-III）测试来衡量儿童的学前成熟度。在多变量分析中，BDE-153 血清浓度与 WPPSI-III 综合评分呈显著负相关（p=0.011，β=-23.6），同时调整了 PCB-153 和性别因素。在控制了 PCB-118 和性别因素后，BDE-153 血清浓度（p=0.002，β=-29.8）与 WPPSI-III 综合评分呈显著负相关。在调整了 PCB-153 和/或 PCB-118 以及性别因素后，BDE-47、BDE-100 和 BDE-153 与不同的 WPPSI 单项测试分数也呈负相关。PCB-153 和 PCB-118 血清浓度与 WPPSI-III 综合评分和单项测试分数均无统计学显著相关性。这些研究结果表明，PBDE 血清暴露对儿童的学前成熟度有不良影响，PBDE 可能对儿童神经心理发育产生负面影响。
