不同来源的ω-3多不饱和脂肪酸对2型糖尿病血脂异常患者糖脂代谢的影响

[Effects of ω-3 polyunsaturated fatty acids from different sources on glucolipid metabolism in type 2 diabetic patients with dyslipidemia].

作者信息

Wang F, Liu H C, Liu X S, Dong S N, Pan D, Yang L G, Sun G J

机构信息

Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China.

Diabetes Specialist Clinic, Guanlin Hospital, Yixing 214251, China.

出版信息

Zhonghua Yu Fang Yi Xue Za Zhi. 2019 Jun 6;53(6):570-575. doi: 10.3760/cma.j.issn.0253-9624.2019.06.006.

DOI:10.3760/cma.j.issn.0253-9624.2019.06.006

PMID:31177752

Abstract

To determine the effects of ω-3 polyunsaturated fatty acids from different sources on glucolipid metabolism in type 2 diabetic patients with dyslipidemia. We recruited participants from the diabetes specialist clinic at the Guanlin hospital in Yixing city, Jiangsu Province from February 2017 to March 2017. A total of 180 subjects were randomly assigned to 3 g/day fish oil (FO), perilla oil (PO), or fish oil mixed with linseed oil (FLO) for 6 months. The basic conditions and fasting venous blood sample were obtained from each study subject at baseline, after 6 months of intervention. Serum glucose and lipid metabolism were investigated. A total of 156 subjects aged (62.6±8.6) years completed the final follow-up after 6 months (FO,54 subjects; PO,52 subjects; FLO,50 subjects). Among them,59 patients (37.8%) were male. Serum glucose, glycated hemoglobin, C peptide, insulin and homeostasis model assessment-insulin resistance were not significantly different among the three groups after 6 months. Serum triglyceride decreased, whereas high-density lipoprotein cholesterol increased in FO [1.33 (1.05,1.93) mmol/L, (1.36±0.29) mmol/L, respectively] compared with PO [1.71 (1.23, 2.17) mmol/L, (1.23±0.22) mmol/L, respectively] and FLO [1.51 (1.12, 2.22) mmol/L, (1.29±0.30) mmol/L, respectively] (0.05). Serum low-density lipoprotein cholesterol and apolipoprotein B decreased in PO [(2.60±0.57) mmol/L,(0.96±0.23) g/L, respectively] compared with FO [(2.89±0.76) mmol/L, (1.07±0.30) g/L, respectively] (0.05). Serum lipoprotein(a) decreased in FLO [130.7 (63.3,270.6) mg/L] compared with FO [137.4 (58.7,333.2) mg/L] (0.05). Serum free fatty acid decreased in FLO [(0.43±0.15) mmol/L] compared with PO [(0.53±0.22) mmol/L] (0.05). The effects of ω-3 PUFA from different sources on glucose metabolism in type 2 diabetic patients with dyslipidemia are similar. Each of them has a good application prospect in improving lipid metabolism.

摘要

为确定不同来源的ω-3多不饱和脂肪酸对2型糖尿病血脂异常患者糖脂代谢的影响。我们于2017年2月至2017年3月从江苏省宜兴市官林医院糖尿病专科门诊招募参与者。总共180名受试者被随机分为三组，分别每日服用3克鱼油（FO）、紫苏油（PO）或鱼油与亚麻籽油混合油（FLO），为期6个月。在基线期、干预6个月后，获取每位研究对象的基本情况及空腹静脉血样本。对血清葡萄糖和脂质代谢进行研究。共有156名年龄为（62.6±8.6）岁的受试者在6个月后完成了最终随访（FO组54名受试者；PO组52名受试者；FLO组50名受试者）。其中，59例患者（37.8%）为男性。6个月后，三组间血清葡萄糖、糖化血红蛋白、C肽、胰岛素及稳态模型评估胰岛素抵抗无显著差异。与PO组[分别为1.71（1.23，2.17）mmol/L，（1.23±0.22）mmol/L]和FLO组[分别为1.51（1.12，2.22）mmol/L，（1.29±0.30）mmol/L]相比，FO组血清甘油三酯降低，而高密度脂蛋白胆固醇升高[分别为1.33（1.05，1.93）mmol/L，（1.36±0.29）mmol/L]（P<0.05）。与FO组[分别为（2.89±0.76）mmol/L，（1.07±0.30）g/L]相比，PO组血清低密度脂蛋白胆固醇和载脂蛋白B降低[分别为（2.60±0.57）mmol/L，（0.96±0.23）g/L]（P<0.05）。与FO组[137.4（58.7，333.2）mg/L]相比，FLO组血清脂蛋白(a)降低[130.7（63.3，270.6）mg/L]（P<0.05）。与PO组[（0.53±0.22）mmol/L]相比，FLO组血清游离脂肪酸降低[（0.43±0.15）mmol/L]（P<0.05）。不同来源的ω-3多不饱和脂肪酸对2型糖尿病血脂异常患者糖代谢的影响相似。它们在改善脂质代谢方面均具有良好的应用前景。