Facultad de Ciencias Biológicas, Departamento de Química, Universidad Autónoma de Nuevo León, Mexico.
Facultad de Medicina, Departamento de Medicina Interna, Unidad de Hígado, Universidad Autónoma de Nuevo León, Mexico.
J Diabetes Res. 2019 Apr 16;2019:7836820. doi: 10.1155/2019/7836820. eCollection 2019.
Diabetes mellitus (DM) is considered the epidemic of the 21st century. Traditional medicine uses plants to treat DM; many of these have hypoglycemic effects in both animal models and diabetic patients. Our objective was to evaluate the hypoglycemic activity of , , , and on diabetic rats. The methanolic extracts of the plants under study were obtained by Soxhlet extraction. Toxicity was evaluated on ; the antioxidant potential was evaluated using the DPPH technique. Hypoglycemic capacity at doses of 250 and 500 mg/kg was tested on Wistar rats with diabetes induced by alloxan (120 mg/kg). The toxicity on was null for the extracts of and , moderate for , and highly toxic for . The relevant extract of var. mexicana showed antioxidant activity. Three plants of the studied plants showed hypoglycemic activity: ( = 0.0142), ( = 0.0112), and ( = 0.0078); was the one that showed the greatest reduction in glucose levels at a lower dose.
糖尿病（DM）被认为是 21 世纪的流行病。传统医学使用植物来治疗 DM；许多这些植物在动物模型和糖尿病患者中都有降血糖作用。我们的目的是评估,,,, 和 对糖尿病大鼠的降血糖活性。通过索氏提取法从研究植物中获得了植物的甲醇提取物。在 上评估了毒性；使用 DPPH 技术评估了抗氧化潜力。用 250 和 500mg/kg 的剂量在 120mg/kg 链脲佐菌素诱导的糖尿病 Wistar 大鼠上测试了降血糖能力。 对 提取物的毒性为 、 和 ，中度毒性为 ，高度毒性为 。相关的 变种提取物具有抗氧化活性。在所研究的三种植物中，有三种植物表现出降血糖活性： （ = 0.0142）， （ = 0.0112）和 （ = 0.0078）；在较低剂量下， 显示出最大的降血糖效果。
