Thent Zar Chi, Das Srijit, Zaidun Nurul Hannim
Anatomy Discipline, Basic Medical Science Cluster, Faculty of Medicine, Sungai Buloh Campus, 47000 Selangor, Universiti Teknologi MARA, Malaysia.
Department of Anatomy, Faculty of Medicine, 53000 Cheras, Universiti Kebangsaan, Malaysia.
Curr Drug Deliv. 2018;15(4):453-460. doi: 10.2174/1567201814666170525122224.
The incidence of diabetes mellitus has increased drastically over the past few decades. This oxidant-antioxidant imbalance resulting in complication of diabetes mellitus includes macro- and microvascular complications. Resistance to conventional treatment and patient compliance has paved the way to the usage of effective natural products and supplements. Momordica charantia (bitter gourd) is widely consumed in many parts of Malaysia as a vegetable. Momordica charantia (MC) is mainly used in the management of diabetes mellitus.
The present review discusses the literature concerning the antidiabetic and antioxidant properties of MC focusing on the complication of diabetes mellitus along with its mode of delivery. We found that among the whole part of MC, its fruit extract has been widely studied, therapeutically. The evidence based analysis of the beneficiary effects of MC on the different organs involved in diabetes complication is also highlighted. This review elucidated an essential understanding of MC based drug delivery system in both clinical and experimental studies and appraised the great potential of the protein based MC extract against diabetes mellitus.
The review paper is believed to assist the researchers and medical personnel in treating diabetic associated complications.
在过去几十年中，糖尿病的发病率急剧上升。这种导致糖尿病并发症的氧化应激-抗氧化失衡包括大血管和微血管并发症。对传统治疗的耐药性以及患者的依从性为有效天然产物和补充剂的使用铺平了道路。苦瓜在马来西亚的许多地区作为蔬菜被广泛食用。苦瓜主要用于糖尿病的管理。
本综述讨论了有关苦瓜抗糖尿病和抗氧化特性的文献，重点关注糖尿病并发症及其给药方式。我们发现，在苦瓜的整个部分中，其果实提取物在治疗方面得到了广泛研究。还强调了对苦瓜对糖尿病并发症所涉及的不同器官有益作用的循证分析。本综述阐明了在临床和实验研究中对基于苦瓜的药物递送系统的基本理解，并评估了基于蛋白质的苦瓜提取物抗糖尿病的巨大潜力。
该综述文章有望帮助研究人员和医务人员治疗糖尿病相关并发症。
