Trost Barry M, Kalnmals Christopher A
Department of Chemistry, Stanford University, 333 Campus Drive, Stanford, CA, 94305, USA.
Chemistry. 2019 Aug 27;25(48):11193-11213. doi: 10.1002/chem.201902019. Epub 2019 Jul 12.
Sulfones are flexible functional groups that can act as nucleophiles, electrophiles, or even radicals. Changing the reaction conditions can completely alter the reactivity of a sulfonyl group, and as a result, molecules bearing multiple sulfones are versatile building blocks. This Review highlights the unique ability of 1,1- and 1,2-bis(sulfones) to masquerade as a vast array of reactive synthons including methane polyanions, vinyl cations, and all-carbon dipoles that would be difficult or impossible to access directly.
砜是一种灵活的官能团，可作为亲核试剂、亲电试剂，甚至自由基。改变反应条件可完全改变砜基的反应活性，因此，含有多个砜基的分子是多功能的结构单元。本综述强调了1,1 -和1,2 -双（砜）独特的能力，它们能够伪装成大量活性合成子，包括甲烷聚阴离子、乙烯基阳离子和难以直接获得或无法直接获得的全碳偶极子。
