Seetharaman Rajasekar, Mahmood Anjum, Kshatriya Prashant, Patel Divyang, Srivastava Anand
GIOSTAR Research Inc. Pvt. Ltd., Ahmedabad, Gujrat, India.
Global Institute of Stem Cell Therapy and Research, 4660 La Jolla Village Drive, San Diego, CA 92122, USA.
Case Rep Dermatol Med. 2019 May 2;2019:8309103. doi: 10.1155/2019/8309103. eCollection 2019.
Psoriasis, an autoimmune disease, affects a vast number of peoples around the world. In this report, we discuss our findings about a scalp psoriasis suffering patient with a Psoriasis Scalp Severity Index (PSSI) score of 28, who was treated with Mesenchymal stem cell conditioned media (MSC-CM). Remarkably, complete regression was recorded within a treatment period of one month only (PSSI score of 0). A number of bioactive factors like cytokines and growth factors secreted by MSCs in the conditioned medium are very likely to be the principle molecules which play a vital role in skin regeneration. Treatment using MSC-CM appears to be an effective tool for tackling the psoriatic problem and, thus, may offer a new avenue of therapy which could be considered as an alternative approach to overcome the limitations of the cell-based therapy.
银屑病是一种自身免疫性疾病，影响着世界各地大量的人群。在本报告中，我们讨论了对一名头皮银屑病患者的研究结果，该患者的头皮银屑病严重程度指数（PSSI）评分为28，接受了间充质干细胞条件培养基（MSC-CM）治疗。值得注意的是，仅在一个月的治疗期内就记录到完全消退（PSSI评分为0）。条件培养基中由间充质干细胞分泌的许多生物活性因子，如细胞因子和生长因子，很可能是在皮肤再生中起关键作用的主要分子。使用MSC-CM进行治疗似乎是解决银屑病问题的有效工具，因此可能提供一种新的治疗途径，可被视为克服基于细胞疗法局限性的替代方法。
