The Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, 1838 Guangzhou North Road, Guangzhou, 510515, Guangdong, China.
Stem Cell Res Ther. 2024 Feb 8;15(1):37. doi: 10.1186/s13287-023-03561-8.
Adipose-derived stem cells (ASCs) are a critical adult stem cell subpopulation and are widely utilized in the fields of regenerative medicine and stem cell research due to their abundance, ease of harvest, and low immunogenicity. ASCs, which are homologous with skin by nature, can treat immune-related skin diseases by promoting skin regeneration and conferring immunosuppressive effects, with the latter being the most important therapeutic mechanism. ASCs regulate the immune response by direct cell-cell communication with immune cells, such as T cells, macrophages, and B cells. In addition to cell-cell interactions, ASCs modulate the immune response indirectly by secreting cytokines, interleukins, growth factors, and extracellular vesicles. The immunomodulatory effects of ASCs have been exploited to treat many immune-related skin diseases with good therapeutic outcomes. This article reviews the mechanisms underlying the immunomodulatory effects of ASCs, as well as progress in research on immune-related skin diseases.
脂肪干细胞（ASCs）是一种重要的成体干细胞亚群，由于其丰富、易于采集和低免疫原性，被广泛应用于再生医学和干细胞研究领域。ASCs 本质上与皮肤同源，可通过促进皮肤再生和发挥免疫抑制作用来治疗与免疫相关的皮肤疾病，后者是最重要的治疗机制。ASCs 通过与免疫细胞（如 T 细胞、巨噬细胞和 B 细胞）的直接细胞间通讯来调节免疫反应。除了细胞间相互作用外，ASCs 还通过分泌细胞因子、白细胞介素、生长因子和细胞外囊泡等间接调节免疫反应。ASCs 的免疫调节作用已被用于治疗许多与免疫相关的皮肤疾病，并取得了良好的治疗效果。本文综述了 ASCs 免疫调节作用的机制，以及在与免疫相关的皮肤疾病研究方面的进展。
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