Schechter B, Feldman M
Naturwissenschaften. 1979 Mar;66(3):140-6. doi: 10.1007/BF00368707.
The role of immunosuppressor cells in preventing host immune rejection of tumor cells is described. The growth of Lewis lung carcinoma (3LL) in syngeneic C57BL mice is accompanied by a weak and transient anti-tumor cytotoxic response that is later on replaced by tumor-enhancing activity. This enhancing activity is correlated with the generation of suppressor cells in 3LL-bearing mice. Such suppressors were demonstrated in two ways: (a) Elimination of the hydrocortisone(HC)-sensitive lymphoid population from tumor-bearing mice (TBM) resulted in a significant increase in the anti-tumor cytotoxic response and in a marked delay in tumor development. It is assumed that HC inactivates precursors of suppressor lymphocytes whereas the mature suppressor cells themselves are HC-resistant. (b) The increased resistance against the tumor could be partially re-suppressed by restoring the HC-treated TBM with spleen or thymus cells from normal C57BL. Suppression, however, was more pronounced if the resistant mice were restored with spleen or thymus cells from TBM. HC-resistant spleen cells from TBM that appear to be enriched for mature suppressor cells were capable of suppressing in vitro the secondary sensitization of spleen cells from TBM against tumor cells.
描述了免疫抑制细胞在预防宿主对肿瘤细胞的免疫排斥中的作用。同基因C57BL小鼠体内Lewis肺癌（3LL）的生长伴随着微弱且短暂的抗肿瘤细胞毒性反应，该反应随后被肿瘤增强活性所取代。这种增强活性与荷3LL小鼠中抑制细胞的产生相关。这种抑制细胞通过两种方式得到证实：（a）从荷瘤小鼠（TBM）中消除对氢化可的松（HC）敏感的淋巴细胞群体，导致抗肿瘤细胞毒性反应显著增加以及肿瘤发展明显延迟。据推测，HC使抑制性淋巴细胞的前体失活，而成熟的抑制细胞本身对HC具有抗性。（b）用正常C57BL小鼠的脾脏或胸腺细胞恢复经HC处理的TBM，可部分重新抑制其对肿瘤增加的抗性。然而，如果用TBM的脾脏或胸腺细胞恢复抗性小鼠，则抑制作用更为明显。来自TBM的对HC具有抗性的脾脏细胞似乎富含成熟的抑制细胞，能够在体外抑制TBM的脾脏细胞对肿瘤细胞的二次致敏。
