Departamento de Química Inorgánica y Bioinorgánica, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Hospital 12 de Octubre i+12, Plaza Ramón y Cajal s/n, 28040 Madrid, Spain.
Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), 28040 Madrid, Spain.
Molecules. 2017 Dec 25;23(1):47. doi: 10.3390/molecules23010047.
This manuscript reviews the recent progress on mesoporous silica nanoparticles as drug delivery systems. Their intrinsic structural, textural and chemical features permit to design versatile multifunctional nanosystems with the capability to target the diseased tissue and release the cargo on demand upon exposition to internal or external stimuli. The degradation rate of these nanocarriers in diverse physiological fluids is overviewed obeying their significance for their potential translation towards clinical applications. To conclude, the balance between the benefits and downsides of this revolutionary nanotechnological tool is also discussed.
这篇手稿综述了介孔硅纳米粒子作为药物传递系统的最新进展。它们内在的结构、质地和化学特性允许设计具有多种功能的多功能纳米系统，能够靶向病变组织，并在受到内部或外部刺激时按需释放货物。本文还概述了这些纳米载体在不同生理流体中的降解速率，这对于它们向临床应用的潜在转化具有重要意义。最后，还讨论了这种革命性纳米技术工具的优缺点之间的平衡。
