Dpto. Química Inorgánica y Bioinorgánica. Universidad Complutense de Madrid. Instituto de Investigación Sanitaria Hospital 12 de Octubre i+12. Plaza Ramón y Cajal s/n, 28040 Madrid, Spain.
Nanoscale. 2017 Oct 26;9(41):15967-15973. doi: 10.1039/c7nr05050j.
A novel singlet-oxygen sensitive drug delivery nanocarrier able to release its cargo after exposure to visible (Vis) light from a common lamp is presented. This nanodevice is based on mesoporous silica nanoparticles (MSN) decorated with porphyrin-caps grafted via reactive oxygen species (ROS)-cleavable linkages. In the presence of Vis light porphyrin-nanocaps produce singlet oxygen molecules that break the sensitive-linker, which triggers pore uncapping and therefore allows the release of the entrapped cargo (topotecan, TOP). This new system takes advantage of the non-toxicity and greater penetration capacity of Vis radiation and a double antitumor effect due to the drug release and the ROS production. In vitro tests with HOS osteosarcoma cancer cells reveal that TOP is able to be released in a controlled fashion inside the tumor cells. This research work constitutes a proof of concept that opens up promising expectations in the search for new alternatives for the treatment of cancer.
本文介绍了一种新型的单线态氧敏药物传递纳米载体，该载体在暴露于普通灯发出的可见光（Vis）后能够释放其货物。这种纳米器件是基于介孔硅纳米粒子（MSN），通过活性氧（ROS）可裂解键合接枝卟啉帽。在 Vis 光存在下，卟啉-纳米帽产生单线态氧分子，打破敏感键，引发孔解封，从而允许被包裹的货物（拓扑替康，TOP）释放。该新系统利用 Vis 辐射的无毒和更大的穿透能力以及由于药物释放和 ROS 产生的双重抗肿瘤作用。用 HOS 骨肉瘤癌细胞进行的体外试验表明，TOP 能够在肿瘤细胞内以受控的方式释放。这项研究工作为寻找新的癌症治疗方法提供了一个有前景的概念验证。
