Xie Chenyao, Zhao Jing, Hua Wenxi, Tan Pei, Chen Yudi, Rui Jingwen, Sun Xiaohan, Fan Jiaying, Wei Xiangyu, Xu Xiaojing, Yang Xiaoqin
School of Biology and Basic Medical Sciences, Soochow University, Suzhou 215123, People's Republic of China.
Medical College, Soochow University, Suzhou 215123, People's Republic of China.
Onco Targets Ther. 2019 May 16;12:3839-3848. doi: 10.2147/OTT.S202617. eCollection 2019.
As an important DNA repair gene, the xeroderma pigmentosum complementation group C (XPC) gene and its functional genetic variants' relationship with chemotherapy response has been extensively studied. To quantitatively elucidate the genetic impact of the rs2228000 and rs2228001 polymorphisms on the response to platinum-based chemotherapy, the present meta-analysis was conducted. A systematic literature search was performed in seven cyber databases until February 20, 2019, for all relevant studies that assessed the relationship between polymorphisms and the response to platinum-based chemotherapy. Odds ratios (ORs) with a 95% confidence interval (95% CI) were measured to assess the strength of the association. R programs were developed to perform the statistical analyses, including calculations of pooled estimates, publication bias and sensitivity analyses, and heterogeneity interpretations. A total of 1,615 patients from 10 studies for the rs2228001 polymorphism were winnowed for further statistical analysis. For the rs2228000 polymorphism, 858 samples from six datasets were included. However, this meta-analysis indicated no significant effect of these two polymorphisms on the response to platinum-based chemotherapy. When stratified according to sample size, country or cancer type, no statistical significance for association was identified in all subgroups. Further sensitivity analysis and publication bias assessment ensured the reliability of the meta-analysis. The pooled estimates suggest that neither the rs2228000 polymorphism nor the rs2228001 polymorphism contributes to the genetic predisposition for an altered response to platinum-based chemotherapy. Considering the limitations of our present meta-analysis, more studies with large-scale cohorts and rigorous methods are needed to validate our results.
作为一种重要的DNA修复基因，着色性干皮病C互补组（XPC）基因及其功能遗传变异与化疗反应的关系已得到广泛研究。为了定量阐明rs2228000和rs2228001多态性对铂类化疗反应的遗传影响，进行了本荟萃分析。在7个网络数据库中进行了系统的文献检索，截至2019年2月20日，查找所有评估多态性与铂类化疗反应之间关系的相关研究。测量比值比（OR）及95%置信区间（95%CI）以评估关联强度。开发了R程序进行统计分析，包括合并估计值的计算、发表偏倚和敏感性分析以及异质性解释。对rs2228001多态性的10项研究中的1615例患者进行筛选以进行进一步的统计分析。对于rs2228000多态性，纳入了来自6个数据集的858个样本。然而，本荟萃分析表明这两种多态性对铂类化疗反应无显著影响。按样本量、国家或癌症类型分层时，所有亚组均未发现关联具有统计学意义。进一步的敏感性分析和发表偏倚评估确保了荟萃分析的可靠性。合并估计值表明，rs2228000多态性和rs2228001多态性均未导致对铂类化疗反应改变的遗传易感性。考虑到我们目前荟萃分析的局限性，需要更多采用大规模队列和严格方法的研究来验证我们的结果。
