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基因多态性与铂类化疗疗效：综述

Genetic Polymorphisms and the Efficacy of Platinum-Based Chemotherapy: Review.

作者信息

Afifah Nadiya Nurul, Diantini Ajeng, Intania Ruri, Abdulah Rizky, Barliana Melisa I

机构信息

Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, Indonesia.

Center of Excellence in Higher Education for Pharmaceutical Care Innovation, Universitas Padjadjaran, Bandung, Indonesia.

出版信息

Pharmgenomics Pers Med. 2020 Oct 8;13:427-444. doi: 10.2147/PGPM.S267625. eCollection 2020.

DOI:10.2147/PGPM.S267625
PMID:33116759
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7549502/
Abstract

Previous studies have indicated that genetic variations in individuals may result in changes in gene expression and amino acids. The effect of these changes may lead to different responses to platinum-based chemotherapy. A vast response rate interval and a short survival rate indicate that the efficacy and efficiency of the selection of chemotherapy have not been optimized. This article aims to illustrate the potential relationship of various genetic polymorphisms in response to platinum-based chemotherapy for several types of cancer. This review was conducted using articles from the last three- and five-year periods (2014-2019) that use gene polymorphism and its relationship to the efficacy of platinum-based chemotherapy as their theme. A total of 26 out of 488 relevant articles were included based on specific criteria. Through various mechanisms, genes, including ERCC1, ERCC2/XPD, XPC, XPA, XRCC1, APE-1, PARP1, OGG1, ABCC2, MRP, GSTP1, GSTM1, GSTT1, MATE1, and OCT2, have been associated with patient response to platinum-based chemotherapy. We conclude that genetic polymorphism analysis is recommended for the management of cancer so that each patient can be administered therapy based on his or her genetic profile to achieve an effective and efficient outcome.

摘要

先前的研究表明，个体的基因变异可能导致基因表达和氨基酸的变化。这些变化的影响可能导致对铂类化疗产生不同的反应。较大的反应率区间和较短的生存率表明化疗选择的疗效和效率尚未得到优化。本文旨在阐述几种癌症对铂类化疗反应中各种基因多态性的潜在关系。本综述使用了过去三年和五年（2014 - 2019年）以基因多态性及其与铂类化疗疗效的关系为主题的文章。根据特定标准，在488篇相关文章中总共纳入了26篇。通过各种机制，包括ERCC1、ERCC2/XPD、XPC、XPA、XRCC1、APE - 1、PARP1、OGG1、ABCC2、MRP、GSTP1、GSTM1、GSTT1、MATE1和OCT2在内的基因已与患者对铂类化疗的反应相关联。我们得出结论，建议对癌症治疗进行基因多态性分析，以便根据每位患者的基因谱进行治疗，从而实现有效且高效的治疗效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fb7/7549502/a4fe4c8afb50/PGPM-13-427-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fb7/7549502/d85278bb617d/PGPM-13-427-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fb7/7549502/4def8ab9b949/PGPM-13-427-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fb7/7549502/fe53c44082a4/PGPM-13-427-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fb7/7549502/a4fe4c8afb50/PGPM-13-427-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fb7/7549502/d85278bb617d/PGPM-13-427-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fb7/7549502/4def8ab9b949/PGPM-13-427-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fb7/7549502/fe53c44082a4/PGPM-13-427-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fb7/7549502/a4fe4c8afb50/PGPM-13-427-g0004.jpg

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