The rs11615, rs2276466, rs2228000 and rs2228001 polymorphisms increase the cervical cancer risk and aggressiveness in the Bangladeshi population.

BACKGROUND

Multiple studies around the world revealed that genetic polymorphism in different genes of the DNA repair system might affect the DNA repair capabilities and accelerate the chances of cervical cancer (CC) development. Therefore, we aimed to evaluate the association of DNA repair gene- rs11615, rs2276466, rs2228000 and rs2228001 polymorphisms and CC susceptibility in the Bangladeshi population.

METHODS

A case-control genetic association study was conducted among 210 patients with diagnostically confirmed CC and 200 healthy volunteers. The -value and OR (odds ratios) with 95% CI (confidence interval) were evaluated to get the level of association.

RESULTS

After the individual analysis of all SNPs, we noticed that rs11615 possessed a significantly lower risk, whereas rs2276466 possessed a significantly elevated risk of CC in all genetic models ( < 0.05). rs2228000 showed a significantly lower risk of CC in TC, TC + CC genotypes and allele model (OR = 0.61, = 0.025; OR = 0.61, = 0.019 and OR = 0.67, = 0.027, respectively), whereas rs2228001 possessed a significantly elevated risk of CC in CA, CA + AA genotypes and allele model (OR = 1.67, = 0.012; OR = 1.69, = 0.009 and OR = 1.42, = 0.022). Besides, rs2276466 (Grade III vs. I + II: OR = 4.01, = 0.003) and rs2228001 (Grade III vs. I + II: OR = 3.38, = 0.003) were connected with high tumor aggressiveness and rs2276466 was also showed a lower risk of CC development in the younger population (<45 years).

CONCLUSION

The findings supported that rs2276466 and rs2228001 polymorphisms increase CC development and aggressiveness, whereas rs11615 and rs2228000 lower the CC risk in the studied population.