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破伤风的临床特征与转归:一项回顾性研究

Clinical features and outcomes of tetanus: a retrospective study.

作者信息

Fan Zhe, Zhao Yue, Wang Shuang, Zhang Feng, Zhuang Chengjun

机构信息

Department of General Surgery, The Third People's Hospital of Dalian, Dalian Medical University, Dalian, People's Republic of China.

Department of General Surgery, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, People's Republic of China.

出版信息

Infect Drug Resist. 2019 May 16;12:1289-1293. doi: 10.2147/IDR.S204650. eCollection 2019.

Abstract

Tetanus is a serious disease resulting in muscle spasm, and even death. A retrospective, single-center study was conducted by analyzing demographic and clinical parameters. The study included 12 males (70.6%) and 5 females (29.4%). The mean age of the patients was 56.71±9.05 years. Patient occupations included farming (47.0%), retired (23.5), homebound (23.5), and workers (6.0%). The causes of patient injuries were as follows: metal injury (52.9%), deep injury (29.4%), electrical injury (5.9%), maxillofacial region and knee injury (5.9%), and skin ulceration (5.9%). The disease duration ranged from 3 to 36 days, and the mean incubation period was 12.65±10.17 days. Four patients had co-morbidities. The infected patients were given tetanus antitoxin (TAT) and antibiotics treatment. One patient was given continuous renal replacement therapy (CRRT) and only one patient died. In our department, although tetanus is a serious disease, with effective treatment, patients have reasonable cure and low death rates.

摘要

破伤风是一种会导致肌肉痉挛甚至死亡的严重疾病。通过分析人口统计学和临床参数进行了一项回顾性单中心研究。该研究纳入了12名男性(70.6%)和5名女性(29.4%)。患者的平均年龄为56.71±9.05岁。患者职业包括务农(47.0%)、退休(23.5%)、居家(23.5%)和工人(6.0%)。患者受伤原因如下:金属伤(52.9%)、深部伤(29.4%)、电击伤(5.9%)、颌面及膝部伤(5.9%)和皮肤溃疡(5.9%)。病程为3至36天,平均潜伏期为12.65±10.17天。4例患者有合并症。感染患者接受了破伤风抗毒素(TAT)和抗生素治疗。1例患者接受了连续性肾脏替代治疗(CRRT),仅1例患者死亡。在我们科室,虽然破伤风是一种严重疾病,但通过有效治疗,患者有合理的治愈率且死亡率较低。

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