Division of Pulmonary and Critical Care.
Interventional Pulmonology, University of Chicago Medical Center, Chicago, Illinois.
Ann Am Thorac Soc. 2019 Oct;16(10):1220-1229. doi: 10.1513/AnnalsATS.201812-892CME.
Bronchoscopic ablative therapies have been applied safely and successfully for the palliation of malignant central airway obstruction and have the potential for treating inoperable peripheral lung tumors. Proper understanding of technology-tissue interaction allows clinicians to optimize tissue effects, avoid intraoperative complications, and predict response to therapy and potential adverse events. This article reviews the basic mechanisms of action and clinical data on bronchoscopic ablation using laser, electrosurgery, photodynamic therapy, cryotherapy, radiofrequency ablation, microwave ablation, and thermal vapor ablation for malignant central airway obstruction and peripheral lung tumors.
经支气管镜消融治疗已安全有效地应用于恶性中央气道阻塞的姑息治疗，并有潜力治疗不可手术的周围型肺部肿瘤。对技术-组织相互作用的正确理解使临床医生能够优化组织效果，避免术中并发症，并预测对治疗和潜在不良事件的反应。本文综述了激光、电外科、光动力疗法、冷冻疗法、射频消融、微波消融和热蒸汽消融治疗恶性中央气道阻塞和周围型肺部肿瘤的基本作用机制和临床数据。
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