Hyslop Alan, Weller Robert
Division of Pulmonary, Critical Care, Sleep and Occupational Medicine, USA.
Indiana University School of Medicine, Indianapolis, IN, USA.
Respir Med Case Rep. 2024 Sep 15;52:102111. doi: 10.1016/j.rmcr.2024.102111. eCollection 2024.
Central airway obstruction (CAO) is generally defined as airflow limitation due to >50 % occlusion and is most commonly due to malignant etiologies. However, benign etiologies, including herpes-simplex-virus (HSV) endobronchial pseudotumor, can occur. Due to the rarity of HSV causing airway obstruction, an evidence-based approach to the bronchoscopic resection and standardization of therapy after removal are lacking. Herein, we present a case of HSV pseudotumor successfully managed by argon-plasma-coagulation (APC) debulking via bronchoscopy and medical management with intravenous foscarnet due to failed treatment with acyclovir for previous HSV lesions.
中央气道阻塞（CAO）通常定义为由于超过50%的阻塞导致的气流受限，最常见的病因是恶性肿瘤。然而，良性病因也可能发生，包括单纯疱疹病毒（HSV）支气管内假瘤。由于HSV导致气道阻塞的情况罕见，目前缺乏基于证据的支气管镜切除方法以及切除后治疗的标准化方案。在此，我们报告一例HSV假瘤病例，该病例通过支气管镜下氩等离子体凝固（APC）减容成功治疗，并因之前的HSV病变使用阿昔洛韦治疗失败，改用静脉注射膦甲酸钠进行药物治疗。
