Tang Jiamin, Zhao Ruifang, Yin Xueqian, Wen Ya, Shi Yidong, Zhu Puxin, Chen Zheng, Zeng Rong, Tan Lin
J Biomed Nanotechnol. 2019 Jul 1;15(7):1432-1442. doi: 10.1166/jbn.2019.2784.
Smart wet-spun fibers for highly programmable release of therapeutic drug have been rarely reported. Herein, thermalresponsive composite fibers were successfully prepared by core-sheath wet-spinning technology in present study. They consisted of a model drug of natural antibacterial berberine chloride hydrate (BCH) and a drug carrier of temperature responsive shape memory polyurethane (SMPU). The obtained composite fibers featured with well-controlled microscopic morphologies, exhibiting significantly enhanced thermal stability and superb mechanical properties. drug release test and corresponding release kinetics study were performed for investigation of BCH's release behavior. Results demonstrated that the release behaviors of BCH from the core-sheath fibers were pH-dependent, influenced by both diffusion from pore channels and the solubility of BCH in the release mediums, and BCH imbedded only in core part showed a longer release period compared with that in both core and sheath parts of the composite fibers. More importantly, the release rate of BCH can be simply controlled by changing the initial shapes of fibers through stretching and fixation of the stretched deformations. Furthermore, the antibacterial durability of the smart composites fibers was demonstrated and tracked according to the growth inhibition against both negative and positive bacteria strains. All these results suggest that the developed composite fibers can be promising candidates as smart drug delivery vehicles for highly adjustable doses of target drugs towards practical applications.
用于高度可编程释放治疗药物的智能湿法纺丝纤维鲜有报道。在本研究中，通过核壳湿法纺丝技术成功制备了热响应复合纤维。它们由天然抗菌药物水合氯化小檗碱（BCH）的模型药物和温度响应形状记忆聚氨酯（SMPU）的药物载体组成。所获得的复合纤维具有可控的微观形态，表现出显著增强的热稳定性和优异的机械性能。进行了药物释放测试和相应的释放动力学研究，以考察BCH的释放行为。结果表明，BCH从核壳纤维中的释放行为依赖于pH值，受孔道扩散和BCH在释放介质中的溶解度影响，并且仅嵌入核部分的BCH与复合纤维的核和壳部分中的BCH相比具有更长的释放期。更重要的是，通过拉伸和固定拉伸变形来改变纤维的初始形状，可以简单地控制BCH的释放速率。此外，根据对阴性和阳性细菌菌株的生长抑制作用，证明并跟踪了智能复合纤维的抗菌耐久性。所有这些结果表明，所开发的复合纤维有望成为智能药物递送载体，用于向实际应用中高度可调剂量的靶标药物。
