East London Foundation NHS Trust, 5-7 Rush Court, Bedford MK40 3JT, UK; University College, London, UK; King's College, London, UK.
Epilepsy Behav. 2019 Nov;100(Pt B):106210. doi: 10.1016/j.yebeh.2019.03.015. Epub 2019 Jun 10.
There is a substantial body of research on social cognition in adults with epilepsy, and in broad categories such as focal and generalized epilepsies, but much less has been written about social cognition in children with epilepsy (CWE), and in childhood-onset epilepsy syndromes specifically. In several of these syndromes, autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD), two disorders with social cognitive impairments, are reported. There is strong evidence for social cognitive deficits in juvenile myoclonic epilepsy (JME). There is also a considerable amount of evidence for such deficits in a number of syndromes that may be associated with ASD or ADHD, including West syndrome (WS), Dravet syndrome (DS), and the Landau-Kleffner syndrome (LKS). However, the evidence is of variable quality and incomplete across the range of childhood epilepsy syndromes. In some syndromes, childhood epilepsy substantially increases the risk of severe social cognitive impairment, which may persist after the seizures remit. This paper presents an overview of current research on social cognition in childhood epilepsy, with a particular focus on syndromes with a high prevalence of autistic and behavioral comorbidities. Social cognitive impairments represent a considerable additional challenge for patients and caregivers. Early diagnosis and intervention might significantly improve long-term social cognitive outcomes, highlighting the need for greater awareness among clinicians of this important topic. This article is part of the Special Issue "Epilepsy and social cognition across the lifespan".
有大量关于成人癫痫患者社会认知的研究，以及在局灶性和全面性癫痫等广泛类别中，但关于癫痫儿童（CWE），特别是儿童期起病的癫痫综合征中的社会认知的研究要少得多。在这些综合征中的几个中，报道了自闭症谱系障碍（ASD）和注意缺陷多动障碍（ADHD）两种具有社会认知障碍的疾病。青少年肌阵挛性癫痫（JME）存在明显的社会认知缺陷的证据。在许多可能与 ASD 或 ADHD 相关的综合征中，包括 West 综合征（WS）、Dravet 综合征（DS）和 Landau-Kleffner 综合征（LKS），也有大量此类缺陷的证据。然而，证据的质量在各种儿童癫痫综合征中存在差异且不完整。在某些综合征中，儿童癫痫大大增加了严重社会认知障碍的风险，这种障碍可能在癫痫发作缓解后仍然存在。本文概述了当前关于儿童癫痫社会认知的研究，特别关注具有高自闭症和行为共病患病率的综合征。社会认知障碍对患者和照顾者来说是一个相当大的额外挑战。早期诊断和干预可能会显著改善长期的社会认知结果，这凸显了临床医生对这一重要主题的更高认识的必要性。本文是特刊“整个生命周期的癫痫和社会认知”的一部分。
