Wilpizeski C R, Lowry L D
Am J Otolaryngol. 1987 Jan-Feb;8(1):7-12. doi: 10.1016/s0196-0709(87)80012-1.
Nonrestrained squirrel monkeys were rotated repeatedly in the horizontal plane once per day for preset times or until a vomiting response occurred. Emesis latencies and frequencies were recorded. Some subjects were fed fresh banana immediately before and after each rotation. The amount consumed provided a measure of conditioned food aversion or feeding suppression. A two-factor model of the motion-sickness syndrome was formulated to account for the data. According to the model, appropriate stimulation of the semicircular canals accompanied by visual and proprioceptive stimulation generates two independent physiologic processes or states: an objective emesis and a subjective nausea process. The emesis process is revealed by vomiting responses and the nausea process is inferred from the appearance of conditioned food aversion. Susceptible monkeys (type I) and resistant monkeys (type II) have different emesis processes, but both have similar nausea processes. Refractory monkeys have no well-developed emesis or nausea processes. Time and order characteristics of the motion-sickness syndrome depend on specific interactions of emesis and nausea processes.
将未受约束的松鼠猴每天在水平面上重复旋转一次，持续预设时间或直至出现呕吐反应。记录呕吐潜伏期和频率。一些实验对象在每次旋转前后立即喂食新鲜香蕉。所消耗的量提供了一种条件性食物厌恶或进食抑制的度量。构建了一个晕动病综合征的双因素模型来解释这些数据。根据该模型，伴有视觉和本体感觉刺激的半规管的适当刺激会产生两个独立的生理过程或状态：客观呕吐和主观恶心过程。呕吐反应揭示了呕吐过程，而条件性食物厌恶的出现则推断出恶心过程。易感性猴子（I型）和抗性猴子（II型）有不同的呕吐过程，但两者有相似的恶心过程。难治性猴子没有发达的呕吐或恶心过程。晕动病综合征的时间和顺序特征取决于呕吐和恶心过程的特定相互作用。
