PD-1 CD8 resident memory T cells balance immunity and fibrotic sequelae.

CD8 tissue-resident memory T (T) cells provide frontline immunity in mucosal tissues. The mechanisms regulating CD8 T maintenance, heterogeneity, and protective and pathological functions are largely elusive. Here, we identify a population of CD8 T cells that is maintained by major histocompatibility complex class I (MHC-I) signaling, and CD80 and CD86 costimulation after acute influenza infection. These T cells have both exhausted-like phenotypes and memory features and provide heterologous immunity against secondary infection. PD-L1 blockade after the resolution of primary infection promotes the rejuvenation of these exhausted-like T cells, restoring protective immunity at the cost of promoting postinfection inflammatory and fibrotic sequelae. Thus, PD-1 serves to limit the pathogenic capacity of exhausted-like T cells at the memory phase. Our data indicate that T cell exhaustion is the result of a tissue-specific cellular adaptation that balances fibrotic sequelae with protective immunity.