Renou G, Sénéchal G, Sterkers J M
Ann Otolaryngol Chir Cervicofac. 1978 Oct-Nov;95(10-11):691-4.
A case is reported of total bilateral cochleo-vestibular destruction following instillation of Framycetin into the middle ear, under pressure, through a transtympanic drain. Toxicity of Framycetin after local use is exceptional and only one case, reported by Ransome, was found in the published literature. The interest of this observation is that, by using puncture of the foot of the stapes, it was possible to find Framycetin in the perilymphatic liquid three weeks after the injection of the product.
据报道,有一例通过鼓膜造口引流在压力下将硫酸新霉素滴入中耳后导致双侧耳蜗-前庭完全破坏的病例。硫酸新霉素局部使用后的毒性非常罕见,在已发表的文献中仅发现Ransome报道的一例。该观察结果的意义在于,通过镫骨足板穿刺,在注射该产品三周后能够在淋巴液中发现硫酸新霉素。