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潜在流行传染病的症状监测:中非加蓬两个卫生中心麻疹疫情的检测

Syndromic surveillance of potentially epidemic infectious diseases: Detection of a measles epidemic in two health centers in Gabon, Central Africa.

作者信息

Sir-Ondo-Enguier Pater Noster, Ngoungou Edgard Brice, Nghomo Yves-Noel, Boundenga Larson, Moupiga-Ndong Priscille, Ibinga Euloge, Deparis Xavier, Lékana-Douki Jean-Bernard

机构信息

UMR 912 Sciences Economiques et Sociales de la Santé et Traitement de I'Information Médicale, Université d'Aix-Marseille, Marseille, France.

Unité, Evolution, Épidémiologie et Résistances Parasitaires, Centre International de Recherches Médicales de Franceville - CIRMF, Franceville, Gabon.

出版信息

Infect Dis Rep. 2019 May 23;11(1):7701. doi: 10.4081/idr.2019.7701. eCollection 2019 Feb 26.

DOI:10.4081/idr.2019.7701
PMID:31205640
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6547028/
Abstract

Measles is a respiratory disease caused by the measles virus (MV) belonging to the family and the genus. Due to a failure in maintaining immunization coverage in some countries, measles is a re-emerging disease in the human population, especially in Africa. The aim of this study was to describe a measles epidemic in Gabon. At first, a syndromic surveillance was set up. Blood samples from febrile patients with maculopapular rash were taken and sent to the measles reference center in Cameroon for laboratory confirmation. Between March and May 2016, 79 clinically suspected cases were reported including 82.3% (n=65) and 17.7% (n=14) in Oyem and Libreville, respectively. In total, 39.2% (n=31) of children were 11 months-old, 34.2% (n=27) were children aged 1 to 4 years, 11.4% (n=9) were older children from 5 to 9 years, 6.3% (n=5) of children were aged 10 to 15 years and 8.9% (n=7) were 15 years and older. 53.3% (16/30) were laboratory confirmed. This measles outbreak reiterates the importance of maintaining a high level of vaccine coverage in Gabon for vaccine-preventable diseases, as well as the usefulness of a near-real-time surveillance system for the detection of infectious diseases.

摘要

麻疹是一种由属于副粘病毒科麻疹病毒属的麻疹病毒引起的呼吸道疾病。由于一些国家在维持免疫接种覆盖率方面存在不足,麻疹在人群中再度出现,尤其是在非洲。本研究的目的是描述加蓬的一次麻疹疫情。首先,建立了症状监测。采集了出现斑丘疹的发热患者的血样,并送往喀麦隆的麻疹参考中心进行实验室确诊。在2016年3月至5月期间,共报告了79例临床疑似病例,其中奥耶姆和利伯维尔分别占82.3%(n = 65)和17.7%(n = 14)。总体而言,39.2%(n = 31)的儿童为11个月大,34.2%(n = 27)为1至4岁的儿童,11.4%(n = 9)为5至9岁的大龄儿童,6.3%(n = 5)的儿童为10至15岁,8.9%(n = 7)为15岁及以上。53.3%(16/30)经实验室确诊。这次麻疹疫情再次凸显了加蓬维持针对疫苗可预防疾病的高疫苗接种覆盖率的重要性,以及近乎实时的监测系统在检测传染病方面的有用性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eaa0/6547028/bc97b06800cc/idr-11-1-7701-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eaa0/6547028/169dccd49004/idr-11-1-7701-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eaa0/6547028/f19c1efc1e92/idr-11-1-7701-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eaa0/6547028/a64fb78caa13/idr-11-1-7701-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eaa0/6547028/061c7e1b281f/idr-11-1-7701-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eaa0/6547028/bc97b06800cc/idr-11-1-7701-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eaa0/6547028/169dccd49004/idr-11-1-7701-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eaa0/6547028/f19c1efc1e92/idr-11-1-7701-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eaa0/6547028/a64fb78caa13/idr-11-1-7701-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eaa0/6547028/061c7e1b281f/idr-11-1-7701-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eaa0/6547028/bc97b06800cc/idr-11-1-7701-g005.jpg

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本文引用的文献

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No clinical or biological difference between Chikungunya and Dengue Fever during the 2010 Gabonese outbreak.2010年加蓬疫情期间,基孔肯雅热与登革热在临床或生物学上无差异。
Infect Dis Rep. 2012 Jan 3;4(1):e5. doi: 10.4081/idr.2012.e5. eCollection 2012 Jan 2.
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Measles outbreak response immunization is context-specific: insight from the recent experience of Médecins Sans Frontières.麻疹疫情应对免疫具有特定背景:无国界医生组织近期经验的启示。
PLoS Med. 2013 Nov;10(11):e1001544. doi: 10.1371/journal.pmed.1001544. Epub 2013 Nov 5.
3
Measles in Democratic Republic of Congo: an outbreak description from Katanga, 2010-2011.
刚果民主共和国的麻疹疫情:2010-2011 年加丹加省的疫情描述。
BMC Infect Dis. 2013 May 22;13:232. doi: 10.1186/1471-2334-13-232.
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Early introduction and delayed dissemination of pandemic influenza, Gabon.大流行流感的早期传入和延迟传播,加蓬。
Emerg Infect Dis. 2013 Apr;19(4):644-7. doi: 10.3201/eid1904.111925.
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Measles outbreak in Northern Central African Republic 3 years after the last national immunization campaign.中非共和国北部麻疹疫情爆发,距离上一次全国免疫接种活动已有 3 年。
BMC Infect Dis. 2013 Feb 26;13:103. doi: 10.1186/1471-2334-13-103.
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Measles outbreak in South Africa: epidemiology of laboratory-confirmed measles cases and assessment of intervention, 2009-2011.南非麻疹疫情:2009-2011 年实验室确诊麻疹病例的流行病学和干预评估。
PLoS One. 2013;8(2):e55682. doi: 10.1371/journal.pone.0055682. Epub 2013 Feb 20.
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Measles outbreak investigation in Zaka, Masvingo Province, Zimbabwe, 2010.2010年津巴布韦马斯温戈省扎卡地区麻疹疫情调查
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