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Extracellular vesicles from immortalized mesenchymal stromal cells protect against neonatal hypoxic-ischemic brain injury.永生化间充质基质细胞来源的细胞外囊泡可预防新生儿缺氧缺血性脑损伤。
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Geroscience. 2022 Feb;44(1):293-310. doi: 10.1007/s11357-021-00483-2. Epub 2021 Nov 10.
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Mesenchymal stem cell-based therapy and exosomes in COVID-19: current trends and prospects.基于间充质干细胞的治疗和细胞外囊泡在 COVID-19 中的应用：当前趋势和前景。
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MiR-195-5p Ameliorates Cerebral Ischemia-Reperfusion Injury by Regulating the PTEN-AKT Signaling Pathway.微小RNA-195-5p通过调控PTEN-AKT信号通路改善脑缺血再灌注损伤。
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Extracellular vesicles from skin precursor-derived Schwann cells promote axonal outgrowth and regeneration of motoneurons via Akt/mTOR/p70S6K pathway.皮肤前体细胞来源的施万细胞分泌的细胞外囊泡通过Akt/mTOR/p70S6K信号通路促进运动神经元轴突的生长和再生。
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Mesenchymal Stromal Cell-Derived Extracellular Vesicles Reduce Neuroinflammation, Promote Neural Cell Proliferation and Improve Oligodendrocyte Maturation in Neonatal Hypoxic-Ischemic Brain Injury.间充质基质细胞衍生的细胞外囊泡可减轻新生鼠缺氧缺血性脑损伤中的神经炎症，促进神经细胞增殖并改善少突胶质细胞成熟。
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本文引用的文献

1
Approaches to treat immune hot, altered and cold tumours with combination immunotherapies.采用联合免疫疗法治疗免疫热、改变和冷肿瘤的方法。
Nat Rev Drug Discov. 2019 Mar;18(3):197-218. doi: 10.1038/s41573-018-0007-y.
2
Extracellular vesicles and their immunomodulatory functions in pregnancy.细胞外囊泡及其在妊娠中的免疫调节功能。
Semin Immunopathol. 2018 Sep;40(5):425-437. doi: 10.1007/s00281-018-0680-2. Epub 2018 Apr 3.
3
Human Neural Stem Cell Extracellular Vesicles Improve Tissue and Functional Recovery in the Murine Thromboembolic Stroke Model.人神经干细胞细胞外囊泡改善血栓栓塞性卒中模型小鼠的组织和功能恢复。
Transl Stroke Res. 2018 Oct;9(5):530-539. doi: 10.1007/s12975-017-0599-2. Epub 2017 Dec 28.
4
Concise Review: Developing Best-Practice Models for the Therapeutic Use of Extracellular Vesicles.简明综述：开发细胞外囊泡治疗应用的最佳实践模型。
Stem Cells Transl Med. 2017 Aug;6(8):1730-1739. doi: 10.1002/sctm.17-0055. Epub 2017 Jul 17.
5
Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicles and Their Potential as Novel Immunomodulatory Therapeutic Agents.间充质干/基质细胞衍生的细胞外囊泡及其作为新型免疫调节治疗剂的潜力。
Int J Mol Sci. 2017 Jul 6;18(7):1450. doi: 10.3390/ijms18071450.
6
Mesenchymal Stem Cells: Time to Change the Name!间充质干细胞：是时候改名了！
Stem Cells Transl Med. 2017 Jun;6(6):1445-1451. doi: 10.1002/sctm.17-0051. Epub 2017 Apr 28.
7
Neural Stem Cell Transplantation Induces Stroke Recovery by Upregulating Glutamate Transporter GLT-1 in Astrocytes.神经干细胞移植通过上调星形胶质细胞中的谷氨酸转运体GLT-1诱导中风恢复。
J Neurosci. 2016 Oct 12;36(41):10529-10544. doi: 10.1523/JNEUROSCI.1643-16.2016.
8
Applying extracellular vesicles based therapeutics in clinical trials - an ISEV position paper.应用细胞外囊泡为基础的治疗方法于临床试验——ISEV 立场文件。
J Extracell Vesicles. 2015 Dec 31;4:30087. doi: 10.3402/jev.v4.30087. eCollection 2015.
9
Extracellular Vesicles Improve Post-Stroke Neuroregeneration and Prevent Postischemic Immunosuppression.细胞外囊泡可改善中风后的神经再生并预防缺血后免疫抑制。
Stem Cells Transl Med. 2015 Oct;4(10):1131-43. doi: 10.5966/sctm.2015-0078. Epub 2015 Sep 3.
10
Biological properties of extracellular vesicles and their physiological functions.细胞外囊泡的生物学特性及其生理功能。
J Extracell Vesicles. 2015 May 14;4:27066. doi: 10.3402/jev.v4.27066. eCollection 2015.

Identification of the right cell sources for the production of therapeutically active extracellular vesicles in ischemic stroke.

作者信息

Giebel Bernd, Hermann Dirk M

机构信息

Institute of Transfusion Medicine, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

Department of Neurology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

出版信息

Ann Transl Med. 2019 May;7(9):188. doi: 10.21037/atm.2019.03.49.

DOI:10.21037/atm.2019.03.49
PMID:31205906
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6545303/
Abstract
摘要