Lambrou F H, Snyder R W, Williams G A, Lewandowski M
Department of Ophthalmology, Medical College of Wisconsin, Milwaukee 53226.
Am J Ophthalmol. 1987 Dec 15;104(6):619-23. doi: 10.1016/0002-9394(87)90175-9.
We produced experimental intravitreal fibrin clots in rabbits that had previous gas compression of the vitreous or intact vitreous. Twenty-four hours after production of fibrin, the eyes were injected with 25 micrograms of tissue plasminogen activator or physiologic irrigation solution. In the gas compression group (n = 11), all tissue plasminogen activator-treated eyes cleared within six hours of injection; complete clearing was not seen until six days in the physiologic irrigation solution-treated eyes (n = 9). A similar response was seen in the intact vitreous group. No evidence of toxicity was observed as measured by slit-lamp biomicroscopy, intraocular pressure, corneal thickness, electroretinography, or histopathologic examination.
我们在先前有玻璃体气体压缩或玻璃体完整的兔子中制作了实验性玻璃体内纤维蛋白凝块。在产生纤维蛋白24小时后，向眼睛注射25微克组织型纤溶酶原激活剂或生理冲洗液。在气体压缩组（n = 11）中，所有接受组织型纤溶酶原激活剂治疗的眼睛在注射后6小时内凝块清除；而在接受生理冲洗液治疗的眼睛（n = 9）中，直到6天后才出现完全清除。在玻璃体完整组中也观察到类似的反应。通过裂隙灯生物显微镜检查、眼压测量、角膜厚度测量、视网膜电图或组织病理学检查均未观察到毒性证据。
