Tao Rui, Lu Zhaozeng, Ding Ding, Fu Shuhao, Hong Zhen, Liang Xiaoniu, Zheng Li, Xiao Yiqin, Zhao Qianhua
Department of Ophthalmology, Huashan Hospital, Fudan University, Shanghai, China.
Department of Neurology, Huashan Hospital, Fudan University, Shanghai, China.
Alzheimers Dement (Amst). 2019 Jun 6;11:405-414. doi: 10.1016/j.dadm.2019.04.003. eCollection 2019 Dec.
The aim of this study was to investigate retinal thickness as a biomarker for identifying patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD).
The retinal thickness, utilizing the spectral domain optical coherence tomography, was compared among 73 patients with AD, 51 patients with MCI, 67 cognitive normal control (NC) subjects.
The retinal thickness of ganglion cell complex and peripapillary retinal nerve fiber layer decreased in both AD and MCI patients, in comparison with NC subjects (AD vs. NC, < .01; MCI vs. NC, < .01). The inner retinal layers in macular area in MCI exhibited significant thinning compared with NC ( < .001). Remarkable association was found between the retinal thickness and brain volume ( < .05). Better correlation was seen between the inner perifovea retinal thickness and the hippocampal and entorhinal cortex volume (r: 0.427-0.644, < .01).
The retinal thickness, especially the inner retinal layer thickness, is a potentially early AD marker indicating neurodegeneration.
本研究旨在调查视网膜厚度作为识别轻度认知障碍（MCI）和阿尔茨海默病（AD）患者的生物标志物。
利用光谱域光学相干断层扫描技术，比较了73例AD患者、51例MCI患者和67例认知正常对照（NC）受试者的视网膜厚度。
与NC受试者相比，AD和MCI患者的神经节细胞复合体和视乳头周围视网膜神经纤维层的视网膜厚度均降低（AD与NC相比，<0.01；MCI与NC相比，<0.01）。与NC相比，MCI患者黄斑区的视网膜内层显著变薄（<0.001）。视网膜厚度与脑容量之间存在显著相关性（<0.05）。视网膜中央凹周围内层厚度与海马体和内嗅皮质体积之间的相关性更好（r：0.427 - 0.644，<0.01）。
视网膜厚度，尤其是视网膜内层厚度，是一种潜在的早期AD标志物，表明神经退行性变。
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