Su Chen-Ying, Tseng Ching-Li, Wu Shu-Hsuan, Shih Bo-Wu, Chen Yi-Zhou, Fang Hsu-Wei
Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, 1, Sec. 3, Zhongxiao E. Rd., Taipei 10608, Taiwan.
Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, No. 250, Wu-Hsing St., Taipei 110, Taiwan.
Polymers (Basel). 2019 Jun 16;11(6):1050. doi: 10.3390/polym11061050.
In order to perform the multiple functions of disinfection, cleansing, and storage, preservatives are often added to contact lens care solutions. The disadvantage of adding preservatives is that this often causes various eye conditions. However, lens care solutions would not be able to disinfect in the absence of such preservatives. In addition, comfort is an important issue for contact lens wearers due to the long periods of time they are worn. It has been shown that lower friction coefficients are correlated with increased comfort. We have previously developed a multipurpose contact lens care solution in which poly-gamma-glutamic acid (γ-PGA) was the main ingredient. In this study, we investigated the antimicrobial activity and lubricating property of our care solution. We showed that there was a synergetic effect of γ-PGA and chlorine dioxide on antimicrobial activity. We also demonstrated that γ-PGA functioned as a lubricating agent. Our results provided evidence of γ-PGA acting as a multi-functional polymer that could be applied in contact lens care solutions.
为了实现消毒、清洁和储存等多种功能，隐形眼镜护理液中常常添加防腐剂。添加防腐剂的缺点在于，这常常会引发各种眼部问题。然而，若没有这些防腐剂，隐形眼镜护理液将无法进行消毒。此外，由于佩戴时间较长，舒适度对于隐形眼镜佩戴者而言是一个重要问题。研究表明，较低的摩擦系数与舒适度的提高相关。我们之前研发了一种以聚γ-谷氨酸（γ-PGA）为主要成分的多功能隐形眼镜护理液。在本研究中，我们对该护理液的抗菌活性和润滑性能进行了研究。我们发现γ-PGA和二氧化氯在抗菌活性方面存在协同效应。我们还证明了γ-PGA起到了润滑剂的作用。我们的研究结果为γ-PGA作为一种可应用于隐形眼镜护理液的多功能聚合物提供了证据。
