Department Of Ultrasonography, Affiliated Hospital of Jining Medical University, Jining, 272000, China.
Sci Rep. 2019 Jun 17;9(1):8662. doi: 10.1038/s41598-019-45221-z.
To compare the prenatal diagnostic performance as well as appearance of ultrasonic details between 2-dimensional ultrasonography (2DUS) combined with 3-dimensional ultrasonography (3DUS) and 2DUS alone for hypospadias. A total of 47 fetuses were enrolled and examined by 2DUS and then 3DUS. Postnatal follow-up data were obtained and 28 cases were confirmed of hypospadias. Although not statistically significant, there was a trend toward higher AUC (0.85 vs. 0.76; p = 0.08), ACC (85.1 vs. 76.6%; p = 0.22), SEN (85.7 vs. 78.6%; p = 0.63), and SPE (84.2 vs. 73.7%; p = 0.50) for 2DUS combined with 3DUS compared with 2DUS alone. The agreement between both methods was moderate [kappa = 0.592]. Both modalities showed accurately the short penis and blunt tip of the penis. 2DUS in combination with 3DUS showed more cases in other detailed features, such as "chordee", a "hooded" incomplete prepuce, and so on. Overall 2DUS combined with 3DUS showed a trend toward higher performance compared with 2DUS alone for the diagnosis of hypospadias, although the difference was not statistically significant. 3DUS is a useful complement for 2DUS in the diagnosis of fetal hypospadias and may provide more detailed information related to its diagnosis and prognosis.
比较二维超声（2DUS）联合三维超声（3DUS）与单独 2DUS 在尿道下裂产前诊断中的性能及超声细节表现。共纳入 47 例胎儿，均行 2DUS 及 3DUS 检查。获得了产后随访数据，其中 28 例确诊为尿道下裂。虽然无统计学意义，但 2DUS 联合 3DUS 的 AUC（0.85 比 0.76；p=0.08）、ACC（85.1 比 76.6%；p=0.22）、SEN（85.7 比 78.6%；p=0.63）和 SPE（84.2 比 73.7%；p=0.50）均有升高趋势。与单独 2DUS 相比，两种方法的一致性为中度[kappa=0.592]。两种方法均准确显示短阴茎和钝状阴茎尖端。2DUS 联合 3DUS 显示了更多其他详细特征，如“弯曲”、“罩状”不完全包皮等病例。总体而言，2DUS 联合 3DUS 与单独 2DUS 相比，尿道下裂的诊断性能呈升高趋势，但差异无统计学意义。3DUS 是 2DUS 诊断胎儿尿道下裂的有用补充，可提供更多与诊断和预后相关的详细信息。
