Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Garscube Campus, Glasgow, G61 1QH, Scotland, UK.
J Neurol. 2019 Sep;266(9):2334-2337. doi: 10.1007/s00415-019-09425-7. Epub 2019 Jun 17.
Human African trypanosomiasis (HAT), also known as sleeping sickness, is one of the Africa's 'neglected diseases' and is caused by infection with protozoan parasites of the Trypanosoma genus. Transmitted by the bite of the tsetse fly, it puts 70 million people at risk throughout sub-Saharan Africa and is usually fatal if untreated or inadequately treated. In this brief overview, some important recent developments in this disease are outlined. These cover various aspects including a reduction in disease incidence, newly recognised parasite reservoir sites in humans, disease outcome, novel diagnostic methods, new and improved treatment, and disease neuropathogenesis.
人类非洲锥虫病（HAT），也称为昏睡病，是非洲“被忽视的疾病”之一，由原生动物锥虫属的寄生虫感染引起。通过采采蝇的叮咬传播，它使撒哈拉以南非洲地区的 7000 万人面临风险，如果未经治疗或治疗不当，通常是致命的。在这篇简要综述中，概述了该病的一些重要的最新进展。这些进展涵盖了各个方面，包括疾病发病率的降低、人类中新发现的寄生虫储存部位、疾病结局、新的和改进的诊断方法、新的和改进的治疗方法以及疾病的神经发病机制。
