Boujaoude Ziad, Arya Rohan, Shrivastava Aseem, Pratter Melvin, Abouzgheib Wissam
Division of Pulmonary and Critical Care Medicine, Cooper Medical School of Rowan University, Camden, NJ 08103, USA.
Division of Pulmonary and Critical Care Medicine, University of South Carolina School of Medicine, Columbia, SC 29203, USA.
Pulm Med. 2019 May 9;2019:4347852. doi: 10.1155/2019/4347852. eCollection 2019.
The ideal type of sedation for endobronchial ultrasound transbronchial needle aspiration (EBUS-TBNA) is not known. Two previous studies comparing the diagnostic yield between moderate sedation (MS) and deep sedation/general anesthesia (DS/GA) had provided conflicting results with one study clearly favoring the latter. No study had addressed cost. This is concerning for pulmonologists without routine access to anesthesia services. Our objective was to assess the impact of MS and Monitored Anesthesia Care (sedation administered and monitored by an anesthesiologist) on the outcomes and cost of EBUS-TBNA.
We performed a retrospective review of prospectively collected data on consecutive EBUS-TBNA performed under two different types of sedation in a single academic center. A diagnostic TBNA was defined as an aspirate yielding any specific diagnosis or if subsequent surgery or follow-up of nondiagnostic/normal aspirates showed no pathology. Current Medicare time-based allowances were used for professional charges calculation.
There was no difference observed between MS and MAC in regards of the diagnostic yield (92.9% versus 91.9%), procedure duration, number, location, and size of lymph node (LN) sampled, but there were more passes per LN with MAC. The average charges were 74.30 USD for MS and 319.91 for MAC. There were more hypotensive and desaturations episodes with MAC but none required escalation of care.
When performed under MS, EBUS-TBNA has similar diagnostic yield as under MAC but may be associated with less side effects. The difference in sedation cost is modest; however, an additional 245$ for each EBUS done under MAC would have significant cost implications on the health system. These findings are of critical importance for bronchoscopists without routine access to anesthesia services and for optimization of healthcare cost and resource utilization.
目前尚不清楚支气管内超声引导下经支气管针吸活检术(EBUS-TBNA)的理想镇静类型。此前两项比较中度镇静(MS)与深度镇静/全身麻醉(DS/GA)诊断率的研究结果相互矛盾,其中一项研究明显支持后者。尚无研究涉及成本问题。这对于无法常规获得麻醉服务的肺科医生而言是个问题。我们的目的是评估中度镇静和麻醉监护(由麻醉医生实施和监测的镇静)对EBUS-TBNA的结果及成本的影响。
我们对在单一学术中心前瞻性收集的、在两种不同类型镇静下连续进行EBUS-TBNA的数据进行了回顾性分析。诊断性经支气管针吸活检定义为吸出物得出任何特异性诊断,或者如果对非诊断性/正常吸出物进行后续手术或随访未发现病理改变。采用当前医疗保险基于时间的补贴来计算专业费用。
在诊断率(92.9%对91.9%)、操作持续时间、采样淋巴结(LN)的数量、位置和大小方面,MS与麻醉监护之间未观察到差异,但麻醉监护下每个LN的穿刺次数更多。MS的平均费用为74.30美元,麻醉监护为319.91美元。麻醉监护下出现低血压和血氧饱和度下降的情况更多,但均无需加强护理。
在中度镇静下进行EBUS-TBNA时,其诊断率与麻醉监护下相似,但可能副作用更少。镇静成本差异不大;然而,在麻醉监护下进行的每例EBUS额外增加245美元,将对卫生系统产生重大成本影响。这些发现对于无法常规获得麻醉服务的支气管镜检查医生以及优化医疗成本和资源利用至关重要。