Neill M, Kazura J W
Bull World Health Organ. 1979;57(2):329-30.
The effect of diethylcarbamazine was tested in a murine model of Brugia malayi microfilaraemia. A course of therapy similar to that used to treat human infection led to more than a 90% decrease in circulating parasites. Experiments in which different amounts of diethylcarbamazine were given as a single dose indicated that its microfilaricidal activity is dose-dependent. The animal model of B. malayi microfilaraemia may be useful for studies of the mechanism of action and pharmacology of diethylcarbamazine and may be applied to the screening of new microfilaricidal drugs.
在马来布鲁线虫微丝蚴血症的小鼠模型中测试了乙胺嗪的效果。一个类似于用于治疗人类感染的疗程导致循环寄生虫减少了90%以上。以单剂量给予不同量乙胺嗪的实验表明其杀微丝蚴活性是剂量依赖性的。马来布鲁线虫微丝蚴血症的动物模型可能有助于乙胺嗪作用机制和药理学的研究，并且可应用于新型杀微丝蚴药物的筛选。
