Department of Internal Medicine, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Korea.
Department of Biochemistry, Chungbuk National University College of Medicine, Cheongju, Korea.
J Korean Med Sci. 2019 Jun 24;34(24):e171. doi: 10.3346/jkms.2019.34.e171.
Diabetic nephropathy (DN) is the most serious microvascular complication of diabetes mellitus and is one of the leading causes of end stage renal failure. In previous studies, the contribution of genetic susceptibility to DN showed inconsistent results. In this study, we investigated the association between the solute carrier family 2 facilitated glucose transporter member 1 (SLC2A1) polymorphism and DN in Korean patients with type 2 diabetes mellitus (T2DM) according to disease duration.
A total of 846 patients with T2DM (mean age, 61.3 ± 12.3 years; mean duration of T2DM, 10.3 ± 7.9 years; 55.3% men) who visited the Chungbuk National University Hospital were investigated. The polymorphism of the SLC2A1 gene was determined by the real time polymerase chain reaction method. Genotyping results were presented as GG, AG, or AA. A subgroup analysis was performed according to duration of T2DM (≤ 10 years, > 10 years).
The AG + AA genotype showed a significantly higher risk of DN compared with the GG genotype in patients with a type 2 DM duration less than 10 years (12.4% vs. 4.2%; < 0.001). No significant differences were observed in terms of other diabetic complications, including retinopathy, peripheral neuropathy, cardiovascular disease, cerebrovascular disease or peripheral artery disease, according to the genotypes of the SLC2A1 polymorphism.
The SLC2A1 polymorphism was associated with DN in Korean patients with T2DM, particularly in the group with a relatively short disease duration.
糖尿病肾病（DN）是糖尿病最严重的微血管并发症，也是终末期肾衰竭的主要原因之一。在之前的研究中，遗传易感性对 DN 的贡献结果并不一致。在这项研究中，我们根据病程调查了溶质载体家族 2 成员 1（SLC2A1）基因多态性与韩国 2 型糖尿病（T2DM）患者 DN 的关系。
共纳入 846 例 T2DM 患者（平均年龄 61.3±12.3 岁；T2DM 病程 10.3±7.9 年；55.3%为男性），均来自忠北国立大学医院。采用实时聚合酶链反应法检测 SLC2A1 基因多态性。基因型结果表示为 GG、AG 或 AA。根据 T2DM 病程（≤10 年、＞10 年）进行亚组分析。
在 T2DM 病程小于 10 年的患者中，AG+AA 基因型发生 DN 的风险明显高于 GG 基因型（12.4%比 4.2%；＜0.001）。根据 SLC2A1 基因多态性的基因型，其他糖尿病并发症如视网膜病变、周围神经病变、心血管疾病、脑血管疾病或外周动脉疾病无显著差异。
SLC2A1 基因多态性与韩国 T2DM 患者的 DN 相关，尤其是在病程较短的患者中。
