今天的 CRISPR 流水线存在太多妥协。
Too Much Compromise in Today's CRISPR Pipelines.
机构信息
Data Science, Inscripta, Inc., Boulder, Colorado.
出版信息
CRISPR J. 2019 Jun;2(3):143-145. doi: 10.1089/crispr.2019.0015.
Abstract
CRISPR-based editing is a revolutionary tool for genome engineering and discovery. The pace of innovation in this young field is truly astonishing, and yet significant gaps remain in the set of capabilities offered. In particular, scalable (massively parallel and multiplex) editing is only available for a small variety of edit types, placing fundamental limits on the kinds of studies researchers can perform. Additional advancements are needed to realize the full potential of the technology.
摘要
基于 CRISPR 的编辑是基因组工程和发现的革命性工具。这个年轻领域的创新步伐确实令人惊讶，但提供的功能集仍然存在重大差距。特别是，可扩展（大规模并行和多路复用）编辑仅适用于少数几种编辑类型，这对研究人员可以进行的研究种类施加了基本限制。需要进一步的进展来实现该技术的全部潜力。
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