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比较中期妊娠手术流产的术前和术后日期。

Comparing preoperative dating and postoperative dating for second-trimester surgical abortions.

机构信息

Department of Obstetrics and Gynecology, University of California, Davis.

Department of Public Health Sciences, University of California, Davis.

出版信息

Contraception. 2020 Jan;101(1):5-9. doi: 10.1016/j.contraception.2019.06.008. Epub 2019 Jun 19.

Abstract

OBJECTIVES

To assess relationships between preoperative and postoperative dating of second-trimester surgical abortion.

STUDY DESIGN

We used a deidentified institutional database to extract demographic, dating and pathology data for surgical abortions performed at 14 to 23-6/7 weeks' gestational age (GA) from 9/2015 to 5/2017. We excluded women with multiple gestations, fetal anomalies and missing fetal biometric measurements. We assigned preoperative GA by ultrasonography for unknown last menstrual period (LMP) or when discrepancy between sonographic and LMP dating exceeded 7 days (<15-6/7 weeks), 10 days (16 to 21-6/7 weeks) or 14 days (22 to 23-6/7 weeks). We determined postoperative GA using fetal foot length pathology standards published by Streeter in 1920 and Drey et al. in 2005. We performed regression analysis to estimate the relationship between pre- and postoperative estimates of GA and to assess demographic effects on these estimates, and χ tests to assess whether fetal foot lengths were concordant with, larger than or smaller than the expected range for the preoperative GA.

RESULTS

The 469 patients analyzed had a median preoperative GA of 19-4/7 weeks (range 14-0/7 to 23-6/7 weeks). Preoperative dating highly correlated with postoperative dating using both pathology standards (r=0.95, p<.001), without any clinically relevant effect by body mass index (Streeter and Drey, p=.79), parity (Streeter p=.89; Drey p=.71), race (Streeter p=.06; Drey p=.07) or GA. Fetal foot lengths were larger than expected in 134 (28.6%) women using Streeter and 17 (3.6%) women using Drey standards (p<.001).

CONCLUSIONS

Preoperative dating and postoperative dating for second-trimester surgical abortion highly correlate. Use of Streeter standards results in more women with a postoperative GA greater than expected compared to Drey standards.

IMPLICATIONS

Increasing legal gestational age restrictions have placed additional burden on clinicians providing safe abortions, but guidelines on gestational age determination are lacking. Contemporary pathology standards consistent with modern practice and universally accepted by abortion providers and gynecologic pathologists are critical to our goal of safe and legal abortion provision.

摘要

目的

评估中期妊娠手术流产的术前和术后日期之间的关系。

研究设计

我们使用一个匿名的机构数据库,提取了 2015 年 9 月至 2017 年 5 月期间在 14 至 23-6/7 孕周(GA)进行的手术流产的人口统计学、日期和病理学数据。我们排除了多胎妊娠、胎儿异常和缺少胎儿生物测量的女性。我们通过超声检查为末次月经(LMP)未知或超声和 LMP 日期差异超过 7 天(<15-6/7 周)、10 天(16 至 21-6/7 周)或 14 天(22 至 23-6/7 周)时分配术前 GA。我们使用 Streeter 于 1920 年和 Drey 等人于 2005 年发表的胎儿足部长度病理学标准来确定术后 GA。我们进行回归分析以估计 GA 的术前和术后估计之间的关系,并评估这些估计对人口统计学的影响,以及 χ 检验以评估胎儿足部长度是否与术前 GA 的预期范围一致、大于或小于预期范围。

结果

分析的 469 名患者的中位术前 GA 为 19-4/7 周(范围为 14-0/7 至 23-6/7 周)。使用两种病理学标准,术前日期与术后日期高度相关(r=0.95,p<.001),体重指数(Streeter 和 Drey,p=.79)、产次(Streeter p=.89;Drey p=.71)、种族(Streeter p=.06;Drey p=.07)对这些估计没有任何临床相关影响。使用 Streeter 标准,134 名(28.6%)女性的胎儿足部长度大于预期,而使用 Drey 标准的有 17 名(3.6%)女性(p<.001)。

结论

中期妊娠手术流产的术前日期和术后日期高度相关。与 Drey 标准相比,使用 Streeter 标准会导致更多女性术后 GA 大于预期。

意义

不断增加的合法妊娠年龄限制给提供安全堕胎的临床医生带来了额外的负担,但缺乏关于妊娠年龄确定的指南。与现代实践一致并被堕胎提供者和妇科病理学家普遍接受的当代病理学标准对于我们提供安全和合法堕胎的目标至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dee/10075327/38fb0956e9c5/nihms-1883934-f0001.jpg

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本文引用的文献

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Committee Opinion No 700: Methods for Estimating the Due Date.委员会意见 700:预产期估计方法。
Obstet Gynecol. 2017 May;129(5):e150-e154. doi: 10.1097/AOG.0000000000002046.
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RETIRED: Determination of gestational age by ultrasound.已退休:超声测定孕周。
J Obstet Gynaecol Can. 2014 Feb;36(2):171-181. doi: 10.1016/S1701-2163(15)30664-2.

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