Thrombosis and Atherosclerosis Research Institute and McMaster University, Hamilton L8L 2X2, ON, Canada.
Thrombosis and Atherosclerosis Research Institute and McMaster University, Hamilton L8L 2X2, ON, Canada.
Acta Biomater. 2019 Aug;94:2-10. doi: 10.1016/j.actbio.2019.06.021. Epub 2019 Jun 18.
Blood-contacting medical devices are an integral part of modern medicine. Such devices may be used for only a few hours or may be implanted for life. Despite advances in biomaterial science, clotting on medical devices remains a common problem. Systemic administration of antiplatelet drugs or anticoagulants is often needed to reduce the risk of clotting. Although effective, such therapy increases the risk of bleeding, which can be fatal. This chapter (a) describes some of the commonly used blood-contacting devices and their potential complications, (b) provides an overview of the mechanisms that drive device-associated clotting, and (c) reviews the strategies employed to attenuate clotting on blood-contacting medical devices. STATEMENT OF SIGNIFICANCE: This paper is part 1 of a series of 4 reviews discussing the problem of biomaterial associated thrombogenicity. The objective was to highlight features of broad agreement and provide commentary on those aspects of the problem that were subject to dispute. We hope that future investigators will update these reviews as new scholarship resolves the uncertainties of today.
接触血液的医疗器械是现代医学的重要组成部分。这些器械的使用时间可能只有几个小时，也可能需要终生植入。尽管生物材料科学取得了进步，但医疗器械上的血栓仍然是一个常见问题。通常需要全身给予抗血小板药物或抗凝剂，以降低血栓形成的风险。尽管这种治疗方法有效，但会增加出血的风险，而出血可能是致命的。本章（a）描述了一些常用的接触血液的器械及其潜在并发症，（b）概述了导致器械相关血栓形成的机制，以及（c）综述了用于减轻接触血液的医疗器械血栓形成的策略。重要性声明：本文是 4 篇综述的第 1 部分，讨论了生物材料相关血栓形成的问题。目的是突出广泛共识的特征，并对该问题存在争议的方面进行评论。我们希望未来的研究人员将随着新的学术研究解决当前的不确定性，更新这些综述。
